For research use only. Not for therapeutic Use.
SMI-4a (TCS-PIM-1-4a) is a poten, selective, cell-permeable and ATP-competitive Pim-1 inhibitor with an IC50 of 24 μM and a Ki of 0.6 μM. SMI-4a also inhibits Pim-2 (IC50 of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. SMI-4a has anticancer activity[1].
SMI-4a (0.5 μM; 1 hour; HEK-293T cells) treatment attenuates the autophosphorylation of tagged Pim-1 in intact cells[1].
| Catalog Number | I003552 |
| CAS Number | 438190-29-5 |
| Synonyms | (5Z)-5-[[3-(trifluoromethyl)phenyl]methylidene]-1,3-thiazolidine-2,4-dione |
| Molecular Formula | C11H6F3NO2S |
| Purity | ≥95% |
| InChI | InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5- |
| InChIKey | NGJLOFCOEOHFKQ-YVMONPNESA-N |
| SMILES | C1=CC(=CC(=C1)C(F)(F)F)C=C2C(=O)NC(=O)S2 |
| Reference | [1]. Xia Z, et al. Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem. 2009 Jan 8;52(1):74-86. |
