For research use only. Not for therapeutic Use.
SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway. SMO-IN-2 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity[1].
SMO-IN-2 (compound 1) has antiproliferative activity against human medulloblastoma cell line Daoy with an IC50 of 0.51 μM[1].
| Catalog Number | I043335 |
| CAS Number | 1822355-27-0 |
| Synonyms | 4-fluoro-N-methyl-N-[1-[2-[(2-methylpyrazol-3-yl)amino]benzoyl]piperidin-4-yl]-2-(trifluoromethyl)benzamide |
| Molecular Formula | C25H25F4N5O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H25F4N5O2/c1-32(23(35)18-8-7-16(26)15-20(18)25(27,28)29)17-10-13-34(14-11-17)24(36)19-5-3-4-6-21(19)31-22-9-12-30-33(22)2/h3-9,12,15,17,31H,10-11,13-14H2,1-2H3 |
| InChIKey | DGYPDRAGFZNVOC-UHFFFAOYSA-N |
| SMILES | CN1C(=CC=N1)NC2=CC=CC=C2C(=O)N3CCC(CC3)N(C)C(=O)C4=C(C=C(C=C4)F)C(F)(F)F |
| Reference | [1]. Ji D, et al. Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors. Bioorg Med Chem. 2020 Mar 15;28(6):115354. |
