For research use only. Not for therapeutic Use.
Smurf1-IN-A01 is a Smurf1 inhibitor. Smurf1-IN-A01 has anticancer activity and can be used for the research of osteoporosis and age-related macular degeneration[1][2][3][4].
Smurf1-IN-A01 (10 μM, 30-60 min) blocked C-type lectin receptor-2d mediated degradation of MyD88 in RAW264.7 cells upon stimulation with β-glucans[1].
Smurf1-IN-A01 (10 μM, 24 h) attenuates the effect of enhancing the ALP activity and Alizarin red S staining in C3H10T1/2 cells[2].
Smurf1-IN-A01 (10 μM, 12 h) decreases ER alpha protein and ERE-luciferase activity in MCF-7 and T47D cells[3].
Smurf1-IN-A01 (10 μM, 2 μL, Injected into vitreous cavity by micro-syringe, single dose) alleviated retinal injury in retinal degeneration model mice[4].
| Catalog Number | I011186 |
| CAS Number | 1007647-73-5 |
| Synonyms | [4-[4-chloro-3-(trifluoromethyl)phenyl]sulfonylpiperazin-1-yl]-[4-(5-methylpyrazol-1-yl)phenyl]methanone |
| Molecular Formula | C22H20ClF3N4O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C22H20ClF3N4O3S/c1-15-8-9-27-30(15)17-4-2-16(3-5-17)21(31)28-10-12-29(13-11-28)34(32,33)18-6-7-20(23)19(14-18)22(24,25)26/h2-9,14H,10-13H2,1H3 |
| InChIKey | QFYLTUDRXBNZFQ-UHFFFAOYSA-N |
| SMILES | CC1=CC=NN1C2=CC=C(C=C2)C(=O)N3CCN(CC3)S(=O)(=O)C4=CC(=C(C=C4)Cl)C(F)(F)F |
| Reference | [1]. Li F, et al. C-type lectin receptor 2d forms homodimers and heterodimers with TLR2 to negatively regulate IRF5-mediated antifungal immunity [J]. Nature Communications, 2023, 14(1): 6718. [2]. Qu M, et al. HSP90β chaperoning SMURF1-mediated LATS proteasomal degradation in the regulation of bone formation [J]. Cellular Signalling, 2023, 102: 110523. [3]. Yang H, et al. SMURF1 facilitates estrogen receptor ɑ signaling in breast cancer cells [J]. Journal of experimental & clinical cancer research, 2018, 37(1): 1-12. [4]. Li D, et al. Smurf1: A possible therapeutic target in dry age-related macular degeneration [J]. Experimental Eye Research, 2023, 233: 109549. [5]. Cao Y, et al. Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci Rep. 2014 May 14;4:4965. |
