SN-38-CO-DMEDA TFA

• CAT Number: I040947
• CAS Number: 1224601-17-5
• Molecular Formula: C29H31F3N4O8
• Molecular Weight: 620.57
• Purity: ≥95%
• Synonyms: [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] N-methyl-N-[2-(methylamino)ethyl]carbamate;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C27H30N4O6.C2HF3O2/c1-5-16-17-11-15(37-26(34)30(4)10-9-28-3)7-8-21(17)29-23-18(16)13-31-22(23)12-20-19(24(31)32)14-36-25(33)27(20,35)6-2;3-2(4,5)1(6)7/h7-8,11-12,28,35H,5-6,9-10,13-14H2,1-4H3;(H,6,7)/t27-;/m0./s1
• InChIKey: OPVMUGFXGHURAV-YCBFMBTMSA-N
• SMILES: CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N(C)CCNC.C(=O)(C(F)(F)F)O

SN-38-CO-DMEDA TFA is the intermediate product for synthesizing antibody-conjugated drug LND1035[1].

Reference

[1]. Xu Zhe, et al. Method for preparation of antibody-conjugated drug LND1035. China, CN113583086 A. 2021-11-02.