SN-38-d3 Glucuronide (0.1 mg/mL in DMSO)

• CAT Number: R027917
• CAS Number: NA
• Molecular Formula: C₂₈H₂₅D₃N₂O₁₁
• Molecular Weight: 571.55
• Purity: ≥95%
• Synonyms: 4-Ethyl-11-(ethyl-d3)-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-9-yl 4-Deoxy-β-D-glucopyranosiduronic Acid (0.1 mg/mL in DMSO); (4S)-4-Ethyl-11-(ethyl-d3)-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyra
• Storage: -20°C
• IUPAC Name: (2S,3S,4S,5R,6S)-6-[[(19S)-19-ethyl-19-hydroxy-14,18-dioxo-10-(2,2,2-trideuterioethyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
• InChI: InChI=1S/C28H28N2O11/c1-3-12-13-7-11(40-26-22(33)20(31)21(32)23(41-26)25(35)36)5-6-17(13)29-19-14(12)9-30-18(19)8-16-15(24(30)34)10-39-27(37)28(16,38)4-2/h5-8,20-23,26,31-33,38H,3-4,9-10H2,1-2H3,(H,35,36)/t20-,21-,22+,23-,26+,28-/m0/s1/i1D3
• InChIKey: SSJQVDUAKDRWTA-VWIRIFJVSA-N
• SMILES: [2H]C([2H])([2H])CC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O)O

SN-38-d3 Glucuronide is a deuterated form of SN-38 Glucuronide, featuring three deuterium atoms. This high-purity isotopically labeled compound is crucial for advanced research in oncology, pharmacokinetics, and drug metabolism. SN-38 is the active metabolite of the chemotherapeutic agent irinotecan, and its glucuronide conjugate plays a significant role in the drug’s metabolism and excretion. SN-38-d3 Glucuronide is particularly valuable for studying the metabolic pathways, drug interactions, and pharmacokinetic profiles of irinotecan and related compounds. The deuterium labeling ensures precise quantification and tracking in biological systems, enhancing the accuracy of mass spectrometric analyses. This compound is an indispensable tool for researchers working on cancer therapies, providing consistent and reliable results in various experimental applications.