SNS-314

• CAT Number: I009543
• CAS Number: 1057249-41-8
• Molecular Formula: C18H15ClN6OS2
• Molecular Weight: 430.93
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: C1=CC(=CC(=C1)Cl)NC(=O)NC2=NC=C(S2)CCNC3=NC=NC4=C3SC=C4

SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.

Reference

[1] Oslob JD, et al. Bioorg Med Chem Lett, 2008, 18(17), 4880-4884.
[2] VanderPorten EC, et al. Mol Cancer Ther, 2009, 8(4), 930-939.
[3] Arbitrario JP, et al. Cancer Chemother Pharmacol, 2010, 65(4), 707-717.