For research use only. Not for therapeutic Use.
SOD1-Derlin-1 inhibitor-1 (compound 56-20) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-1 inhibits SOD1G93A-Derlin-1 complex with an IC50 value of 7.11 μM. SOD1-Derlin-1 inhibitor-1 can be used for the research of amyotrophic lateral sclerosis[1].
SOD1-Derlin-1 inhibitor-1 (50 μM; 16 h) inhibits SOD1G93A-Derlin-1 complex with an IC50 value of 7.11 μM[1].
SOD1-Derlin-1 inhibitor-1 (250 nM; 6 h) interacts with SOD1G93A with a Kd value of 81.1 μM[1].
| Catalog Number | I036462 |
| CAS Number | 840461-03-2 |
| Synonyms | 3-amino-N-(2,4-dibromophenyl)-6-pyridin-3-ylthieno[2,3-b]pyridine-2-carboxamide |
| Molecular Formula | C19H12Br2N4OS |
| Purity | ≥95% |
| InChI | InChI=1S/C19H12Br2N4OS/c20-11-3-5-15(13(21)8-11)24-18(26)17-16(22)12-4-6-14(25-19(12)27-17)10-2-1-7-23-9-10/h1-9H,22H2,(H,24,26) |
| InChIKey | WBPMNEHAAMMXEO-UHFFFAOYSA-N |
| SMILES | C1=CC(=CN=C1)C2=NC3=C(C=C2)C(=C(S3)C(=O)NC4=C(C=C(C=C4)Br)Br)N |
| Reference | [1]. Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9(1):2668. |
