SOD1-Derlin-1 inhibitor-2

• CAT Number: I042026
• CAS Number: 2170170-27-9
• Molecular Formula: C22H18N4OS
• Molecular Weight: 386.47
• Purity: ≥95%
• Synonyms: 3-amino-N-phenyl-N-prop-2-enyl-6-pyridin-3-ylthieno[2,3-b]pyridine-2-carboxamide
• InChI: InChI=1S/C22H18N4OS/c1-2-13-26(16-8-4-3-5-9-16)22(27)20-19(23)17-10-11-18(25-21(17)28-20)15-7-6-12-24-14-15/h2-12,14H,1,13,23H2
• InChIKey: NQWFEZIEBLGBMV-UHFFFAOYSA-N
• SMILES: C=CCN(C1=CC=CC=C1)C(=O)C2=C(C3=C(S2)N=C(C=C3)C4=CN=CC=C4)N

SOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-2 attenuates the interactions between Derlin-1 and SOD1mut. SOD1-Derlin-1 inhibitor-2 can be used for the research of amyotrophic lateral sclerosis (ALS)[1].
SOD1-Derlin-1 inhibitor-2 (compound 56-59; 0.1-100 μM) inhibits the SOD1-Derlin-1 interaction in a dose-dependent manner[1].
SOD1-Derlin-1 inhibitor-2 (compound 56-59; i.c.v.; 3 mM, flow rate 0.15 μL/h) ameliorates ALS pathology in ALS model mice[1].

Reference

[1]. Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9(1):2668.
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