Sodium calcium edetate

• CAT Number: I036469
• CAS Number: 62-33-9
• Molecular Formula: C10H14CaN2Na2O8
• Molecular Weight: 376.29
• Purity: 98%
• Synonyms: Sodium calcium edetate; HSDB4072; HSDB-4072; HSDB 4072
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: Calciate(2-), ((N,N'-1,2-ethanediylbis(N-((carboxy-kappaO)methyl)glycinato-kappaN,kappaO))(4-))-, disodium, (OC-6-21)-
• InChI: InChI=1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;;2*+1/p-2
• InChIKey: YYSAAOAKZCXYLW-UHFFFAOYSA-L
• SMILES: O=C1CN23CCN45CC([O-][Ca+2]24([O-]C(C3)=O)([O-]1)[O-]C(C5)=O)=O.[Na+].[Na+]

Sodium calcium edetate also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning, including both short-term and long-term lead poisoning. Sodium calcium edetate came into medical use in the United States in 1953. It is a chelating agent (CHELATING AGENTS) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.

Reference

1: Bradberry S, Vale A. A comparison of sodium calcium edetate (edetate calcium disodium) and succimer (DMSA) in the treatment of inorganic lead poisoning. Clin Toxicol (Phila). 2009 Nov;47(9):841-58. doi: 10.3109/15563650903321064. PMID: 19852620.
2: Lahaye D, Everaet E, Roosels D. Value of the diagnostic sodium calcium edetate mobilization test as a criterion of lead absorption. J Soc Occup Med. 1989 Winter;39(4):136-40. doi: 10.1093/occmed/39.4.136. PMID: 2516184.
3: Dautel-Morazin A, Dautel MJ, Vulcain JM, Sauleau J. La chélation [Chelation]. Rev Fr Endod. 1991 Sep;10(3):19-27. French. PMID: 1816605.
4: Grier MT, Meyers DG. So much writing, so little science: a review of 37 years of literature on edetate sodium chelation therapy. Ann Pharmacother. 1993 Dec;27(12):1504-9. doi: 10.1177/106002809302701217. PMID: 8305786.
5: Xu Q, Ren Y, Liesche J. Studying Phloem Loading with EDTA-Facilitated Phloem Exudate Collection and Analysis. Methods Mol Biol. 2019;2014:125-133. doi: 10.1007/978-1-4939-9562-2_10. PMID: 31197791.
6: Pedersen MA, Bouchelouche K, Vendelbo MH. 68Ga-PSMA Uptake in Middle Lobe Syndrome. Clin Nucl Med. 2018 Oct;43(10):e376-e377. doi: 10.1097/RLU.0000000000002213. PMID: 30036250.
7: Liou YL, Boyd A, Hylwa SA. What Is Tetrasodium Etidronate and How Is It Related to Formaldehyde? Dermatitis. 2018 Sep/Oct;29(5):289-290. doi: 10.1097/DER.0000000000000408. PMID: 30234615.
8: Morris TW, Sahler LG, Fischer HW. Calcium binding by radiopaque media. Invest Radiol. 1982 Sep-Oct;17(5):501-5. doi: 10.1097/00004424-198209000-00011. PMID: 6815127.
9: Satpati D, Vats K, Sharma R, Kameswaran M, Sarma HD, Dash A. Synthesis, radiolabeling, and evaluation of gastrin releasing peptide receptor antagonist 68 Ga-HBED-CC-RM26. J Labelled Comp Radiopharm. 2019 Oct;62(12):843-849. doi: 10.1002/jlcr.3795. Epub 2019 Aug 13. PMID: 31378967.
10: Bales BC, Grimmond B, Johnson BF, Luttrell MT, Meyer DE, Polyanskaya T, Rishel MJ, Roberts J. Fe-HBED Analogs: A Promising Class of Iron-Chelate Contrast Agents for Magnetic Resonance Imaging. Contrast Media Mol Imaging. 2019 Dec 20;2019:8356931. doi: 10.1155/2019/8356931. PMID: 31969797; PMCID: PMC6961518.