Sodium Colistin Methanesulfonate

• CAT Number: A001228
• CAS Number: 8068-28-8
• Molecular Formula: C58H105N16O28S5 • 5Na
• Molecular Weight: 1749.80
• Purity: ≥95%
• Synonyms: Colistinmethanesulfonic Acid; Colimycin M; Colimycin Sodium Methanesulfonate; Colistimethate; Colistin Sodium Methanesulfonate; Colistin Sulfomethate; Colistin Sulfomethate Sodium; Colistin, Methyl Sulfate Sodium Salt; Colistinat; Coly-Mycin Injectab
• Target: Bacterial
• Solubility: Soluble in DMSO
• Storage: Store at -20C
• IUPAC Name: pentasodium;[2-[(2S,5R,8S,11S,14S,17S,22S)-17-[(1R)-1-hydroxyethyl]-22-[[(2S)-2-[[(2S,3R)-3-hydroxy-2-[[(2S)-2-[[(6R)-6-methyloctanoyl]amino]-4-(sulfonatomethylamino)butanoyl]amino]butanoyl]amino]-4-(sulfonatomethylamino)butanoyl]amino]-5,8-bis(2-methylpropyl)-3,6,9,12,15,18,23-heptaoxo-11,14-bis[2-(sulfonatomethylamino)ethyl]-1,4,7,10,13,16,19-heptazacyclotricos-2-yl]ethylamino]methanesulfonate
• InChI: InChI=1S/C58H110N16O28S5.5Na/c1-9-35(6)12-10-11-13-46(77)65-38(14-20-59-28-103(88,89)90)53(82)74-48(37(8)76)58(87)70-41(17-23-62-31-106(97,98)99)50(79)68-43-19-25-64-57(86)47(36(7)75)73-54(83)42(18-24-63-32-107(100,101)102)67-49(78)39(15-21-60-29-104(91,92)93)69-55(84)44(26-33(2)3)72-56(85)45(27-34(4)5)71-52(81)40(66-51(43)80)16-22-61-30-105(94,95)96;;;;;/h33-45,47-48,59-63,75-76H,9-32H2,1-8H3,(H,64,86)(H,65,77)(H,66,80)(H,67,78)(H,68,79)(H,69,84)(H,70,87)(H,71,81)(H,72,85)(H,73,83)(H,74,82)(H,88,89,90)(H,91,92,93)(H,94,95,96)(H,97,98,99)(H,100,101,102);;;;;/q;5*+1/p-5/t35-,36-,37-,38+,39+,40+,41+,42+,43+,44+,45-,47+,48+;;;;;/m1...../s1
• InChIKey: IQWHCHZFYPIVRV-VLLYEMIKSA-I
• SMILES: CC[C@@H](C)CCCCC(=O)N[C@@H](CCNCS(=O)(=O)[O-])C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCNCS(=O)(=O)[O-])C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CCNCS(=O)(=O)[O-])CC(C)C)CC(C)C)CCNCS(=O)(=O)[O-])CCNCS(=O)(=O)[O-])[C@@H](C)O.[Na+].[Na+].[Na+].[Na+].[Na+]

Sodium Colistin Methanesulfonate（Cat No.:A001228）is a prodrug of colistin, an antibiotic used primarily for severe infections caused by multidrug-resistant Gram-negative bacteria, including Pseudomonas aeruginosa and Acinetobacter baumannii. This methanesulfonate sodium salt enhances colistin’s water solubility, allowing for safer intravenous administration. In the body, it converts to colistin, which disrupts bacterial cell membranes, leading to cell death. Sodium Colistin Methanesulfonate is crucial in treating complex infections in critically ill patients, particularly when other antibiotics are ineffective, and is widely researched for its pharmacokinetics and safety in high-risk cases.

Reference

Falagas, M. E. /Colistin: The Revival of Polymyxins for the Management of Multidrug-resistant Gram-negative Bacterial Infections./ Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 40.9 (2005): 1333-341. www.ncbi.gov. Web. 10 Sept. 2012.Bergen, Philip J. et. al. /Colistin Methanesulfonate Is an Inactive Prodrug of Colistin against Pseudomonas Aeruginosa./ Antimicrobial Agents and Chemotherapy 50.6 (2006): 1953-958. Ncbi.gov. Web. 5 Oct. 2012.