For research use only. Not for therapeutic Use.
Sodium Picosulfate (Sodium Picosulphate) is a contact irritant laxative with oral activity. Sodium Picosulfate inhibits the absorption of water and electrolytes, increasing their production. Sodium Picosulfate can be used in colonoscopy applications[1][2][3][4].
Sodium Picosulfate (400, 800, 1600 μg/mL) has different toxicity to rabbit, rat and human hepatocytes, and rat hepatocytes are the best tolerated[1].
Sodium Picosulfate (10 mg/kg, dissolved in 0.3% tragacanth in water, intragastric administration) has no significant effect on the proliferation of epithelial cells in the ileum and colon of rats[2].
Sodium Picosulfate (2.5, 10 mg/kg/day, dissolved in 0.5% tragacanth gum, intragastric administration) does not cause chronic changes in colon movement in rats[3].
| Catalog Number | A000373 |
| CAS Number | 10040-45-6 |
| Synonyms | disodium;[4-[pyridin-2-yl-(4-sulfonatooxyphenyl)methyl]phenyl] sulfate |
| Molecular Formula | C18H13NNa2O8S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2 |
| InChIKey | GOZDTZWAMGHLDY-UHFFFAOYSA-L |
| SMILES | C1=CC=NC(=C1)C(C2=CC=C(C=C2)OS(=O)(=O)[O-])C3=CC=C(C=C3)OS(=O)(=O)[O-].[Na+].[Na+] |
| Reference | [1]. Nishikawa J, et al. Toxicity study with sodium picosulfate in cultured liver cells of rabbit, rat and man. Arzneimittelforschung. 1981;31(2):321-5. [2]. Geboes K, et al. Effects of ‘contact laxatives’ on intestinal and colonic epithelial cell proliferation. Pharmacology. 1993 Oct;47 Suppl 1:187-95. [3]. Fioramonti J, et al. In vivo motility of rat colon chronically pretreated with sennosides. Pharmacology. 1993 Oct;47 Suppl 1:155-61. [4]. Regev A, et al. Comparison of two bowel preparations for colonoscopy: sodium picosulphate with magnesium citrate versus sulphate-free polyethylene glycol lavage solution. Am J Gastroenterol. 1998 Sep;93(9):1478-82. |
