Sodium salicylate

• CAT Number: A001025
• CAS Number: 54-21-7
• Molecular Formula: C7H5NaO3
• Molecular Weight: 160.1
• Purity: ≥95%
• Synonyms: Sodium 2-hydroxybenzoate
• Target: NF-κB
• Solubility: >7.1mg/mL in DMSO
• Storage: RT
• IUPAC Name: sodium;2-hydroxybenzoate
• InChI: InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
• InChIKey: ABBQHOQBGMUPJH-UHFFFAOYSA-M
• SMILES: C1=CC=C(C(=C1)C(=O)[O-])O.[Na+]

Sodium Salicylate(Cat No.: A001025) is the sodium salt of salicylic acid. As a nonsteroidal anti-inflammatory drug (NSAID), sodium salicylate irreversibly acetylates cyclooxygenases I and II, thereby inhibiting prostaglandin synthesis and associated inflammation and pain. This agent may also activate mitogen-activated protein kinase (p38MAPK), thereby inducing apoptosis in cancer cells.

Overview of Clinical Research

Originator: Catabasis Pharmaceuticals
Developer: Catabasis Pharmaceuticals; Sarepta Therapeutics
Class: Amides; Anti-inflammatories; Antihyperglycaemics; Docosahexaenoic acids; Drug conjugates; Non-opioid analgesics; Salicylates; Small molecules
Mechanism of Action: NF-kappa B inhibitors
Orphan Drug Status: Yes – Duchenne muscular dystrophy
New Molecular Entity: Yes

Reference

[1]: Girard M, Hu D, Pradervand N, Neuenschwander S, Bee G. Chestnut extract but not sodium salicylate decreases the severity of diarrhea and enterotoxigenic Escherichia coli F4 shedding in artificially infected piglets. PLoS One. 2020 Feb 27;15(2):e0214267. doi: 10.1371/journal.pone.0214267. PMID: 32106264; PMCID: PMC7046202.
[2]: Booty SJ, Harding DRK, Whitby CP, Gater M, Chambers P, Singh PM. Sustained- Release Injectable Hydrogel Formulations for Administration of Sodium Salicylate in Broiler Chickens. J Avian Med Surg. 2018 Dec 1;32(4):294-300. doi: 10.1647/2017-303. PMID: 31112642.
[3]: Rutishauser SC, Stone SL. The effect of sodium salicylate on bile secretion in the dog. J Physiol. 1975 Mar;245(3):549-65. doi: 10.1113/jphysiol.1975.sp010861. PMID: 1142217; PMCID: PMC1330805.
[4]: Alexander SJ, Cooper KE, Veale WL. Sodium salicylate: alternate mechanism of central antipyretic action in the rat. Pflugers Arch. 1989 Mar;413(5):451-5. doi: 10.1007/BF00594172. PMID: 2740200.