Sodium taurocholate

• CAT Number: I009480
• CAS Number: 145-42-6
• Molecular Formula: C26H44NNaO7S
• Molecular Weight: 537.6878
• Purity: ≥95%
• Synonyms: sodium 2-((R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethane-1-sulfonate
• Target: Protein Tyrosine Kinase/RTK
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• InChI: InChI=1S/C26H45NO7S.Na/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29;/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34);/q;+1/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-;/m1./s1
• InChIKey: JAJWGJBVLPIOOH-IZYKLYLVSA-M
• SMILES: C[C@H](CCC(NCCS(=O)([O-])=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C.[Na+]

Sodium taurocholate (Cat.No:I009480) is a GPBAR1 protein agonist potentially for the treatment of type 2 diabetes and obesity in rats.

Reference

1:[Sodium taurocholate cotransporting polypeptide deficiency manifesting as cholestatic jaundice in early infancy: a complicated case study]. Song YZ, Deng M.Zhongguo Dang Dai Er Ke Za Zhi. 2017 Mar;19(3):350-354. Chinese. PMID: 28302211 Free Article2:Extended Abstract: Deficiency of Sodium Taurocholate Cotransporting Polypeptide (SLC10A1): A New Inborn Error of Metabolism with an Attenuated Phenotype. Vaz FM, Huidekoper HH, Paulusma CC.Dig Dis. 2017;35(3):259-260. doi: 10.1159/000450984. Epub 2017 Mar 1. PMID: 28249272 3:Phenolic compounds isolated from Dioscorea zingiberensis protect against pancreatic acinar cells necrosis induced by sodium taurocholate. Du D, Jin T, Zhang R, Hu L, Xing Z, Shi N, Shen Y, Gong M.Bioorg Med Chem Lett. 2017 Mar 15;27(6):1467-1470. doi: 10.1016/j.bmcl.2017.01.014. Epub 2017 Jan 7. PMID: 28228364 4:Woodchuck sodium taurocholate cotransporting polypeptide supports low-level hepatitis B and D virus entry. Fu L, Hu H, Liu Y, Jing Z, Li W.Virology. 2017 May;505:1-11. doi: 10.1016/j.virol.2017.02.006. Epub 2017 Feb 14. PMID: 28213271 5:Sodium taurocholate cotransporting polypeptide is the limiting host factor of Hepatitis B Virus infection in macaque and pig hepatocytes. Lempp FA, Wiedtke E, Qu B, Roques P, Chemin I, Vondran FW, Le Grand R, Grimm D, Urban S.Hepatology. 2017 Feb 13. doi: 10.1002/hep.29112. [Epub ahead of print] PMID: 28195359 6:Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status. Ezzikouri S, Chihab H, Elhabazi A, Wakrim L, Benjelloun S.BMC Infect Dis. 2017 Jan 26;17(1):99. doi: 10.1186/s12879-017-2214-2. PMID: 28125961 Free PMC Article7:Acanthopanax versus 3-Methyladenine Ameliorates Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting the Autophagic Pathway in Rats. Wang X, Zhou G, Liu C, Wei R, Zhu S, Xu Y, Wu M, Miao Q.Mediators Inflamm. 2016;2016:8369704. doi: 10.1155/2016/8369704. Epub 2016 Dec 28. PMID: 28115794 Free PMC Article8:Clinical and molecular study of a pediatric patient with sodium taurocholate cotransporting polypeptide deficiency. Deng M, Mao M, Guo L, Chen FP, Wen WR, Song YZ.Exp Ther Med. 2016 Nov;12(5):3294-3300. Epub 2016 Sep 27. PMID: 27882152 Free PMC Article9:Modification of Three Amino Acids in Sodium Taurocholate Cotransporting Polypeptide Renders Mice Susceptible to Infection with Hepatitis D Virus In Vivo. He W, Cao Z, Mao F, Ren B, Li Y, Li D, Li H, Peng B, Yan H, Qi Y, Sun Y, Wang F, Sui J, Li W.J Virol. 2016 Sep 12;90(19):8866-74. doi: 10.1128/JVI.00901-16. Print 2016 Oct 1. PMID: 27466423 Free PMC Article10:Cellular uptake of hepatitis B virus envelope L particles is independent of sodium taurocholate cotransporting polypeptide, but dependent on heparan sulfate proteoglycan. Somiya M, Liu Q, Yoshimoto N, Iijima M, Tatematsu K, Nakai T, Okajima T, Kuroki K, Ueda K, Kuroda S.Virology. 2016 Oct;497:23-32. doi: 10.1016/j.virol.2016.06.024. Epub 2016 Jul 13. PMID: 27420796