Sodium zirconium cyclosilicate

• CAT Number: I042767
• CAS Number: 17141-74-1
• Molecular Formula: H6O9Si3.2Na.Zr
• Molecular Weight: 371.50
• Purity: 95%
• Target: Potassium (K)
• Appearance: Solid
• Storage: Dry, dark and at 2 - 8 °C for six months or -20°C for two years.

Sodium zirconium cyclosilicate（Cat No.:I042767）is an oral potassium binder used to treat hyperkalemia, a condition characterized by elevated potassium levels in the blood. It works by exchanging sodium and hydrogen ions for potassium in the gastrointestinal tract, trapping potassium and allowing it to be excreted through the stool. This process effectively lowers serum potassium levels without affecting other electrolytes. Sodium zirconium cyclosilicate offers a well-tolerated and fast-acting treatment for managing hyperkalemia, providing a safe option for patients with chronic kidney disease, heart failure, or those on potassium-raising medications.

Reference

[1]. Stavros F, et, al. Characterization of structure and function of ZS-9, a K+ selective ion trap. PLoS One. 2014 Dec 22;9(12):e114686.
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[2]. Ash SR, et, al. A phase 2 study on the treatment of hyperkalemia in patients with chronic kidney disease suggests that the selective potassium trap, ZS-9, is safe and efficient. Kidney Int. 2015 Aug;88(2):404-11.
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