Sofosbuvir 3’,5’-Bis-(S)-phosphate

• CAT Number: R025911
• CAS Number: 1337482-17-3
• Molecular Formula: C₃₄H₄₅FN₄O₁₃P₂
• Molecular Weight: 798.69
• Purity: ≥95%
• Synonyms: (2S)-Isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((R)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)amino)propanoate
• Storage: Store at -20°C
• IUPAC Name: propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-4-methyl-3-[[[(2S)-1-oxo-1-propan-2-yloxypropan-2-yl]amino]-phenoxyphosphoryl]oxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
• InChI: InChI=1S/C34H45FN4O13P2/c1-21(2)47-30(41)23(5)37-53(44,50-25-14-10-8-11-15-25)46-20-27-29(34(7,35)32(49-27)39-19-18-28(40)36-33(39)43)52-54(45,51-26-16-12-9-13-17-26)38-24(6)31(42)48-22(3)4/h8-19,21-24,27,29,32H,20H2,1-7H3,(H,37,44)(H,38,45)(H,36,40,43)/t23-,24-,27+,29+,32+,34+,53?,54?/m0/s1
• InChIKey: WVORGVRHMQFKTN-ACVYKXDBSA-N
• SMILES: CC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=CC(=O)NC2=O)(C)F)OP(=O)(NC(C)C(=O)OC(C)C)OC3=CC=CC=C3)OC4=CC=CC=C4

Sofosbuvir 3′,5′-Bis-(S)-phosphate（Cat No.:R025911）, is a metabolite of the antiviral drug Sofosbuvir. Sofosbuvir is a potent direct-acting antiviral medication used to treat chronic hepatitis C virus (HCV) infections. When administered, Sofosbuvir undergoes intracellular metabolism, leading to the formation of its active triphosphate form, Sofosbuvir 3′,5′-Bis-(S)-phosphate. This active metabolite inhibits the HCV RNA-dependent RNA polymerase, NS5B, thereby blocking viral replication and aiding in the elimination of the hepatitis C virus from the body.