For research use only. Not for therapeutic Use.
Sofpironium bromide（Cat No.:I009549）, is a quaternary ammonium compound used as a topical anticholinergic agent for the treatment of hyperhidrosis, a condition characterized by excessive sweating. It works by inhibiting the activity of sweat glands, thereby reducing sweat production. Sofpironium bromide is typically applied as a gel or solution directly to the affected areas. Targeting the cholinergic pathways responsible for sweat gland activation provides localized relief from excessive sweating and helps improve the quality of life for individuals affected by hyperhidrosis.
| Catalog Number | I009549 |
| CAS Number | 1628106-94-4 |
| Synonyms | Sofpironium bromide; BBI-4000; BBI4000; BBI 4000;3-((R)-2-cyclopentyl-2-hydroxy-2-phenylacetoxy)-1-(2-ethoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium bromide |
| Molecular Formula | C22H32BrNO5 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | [(3R)-1-(2-ethoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium-3-yl] (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetate;bromide |
| InChI | InChI=1S/C22H32NO5.BrH/c1-3-27-20(24)16-23(2)14-13-19(15-23)28-21(25)22(26,18-11-7-8-12-18)17-9-5-4-6-10-17;/h4-6,9-10,18-19,26H,3,7-8,11-16H2,1-2H3;1H/q+1;/p-1/t19-,22+,23?;/m1./s1 |
| InChIKey | FIAFMTCUJCWADZ-JOFREBOKSA-M |
| SMILES | CCOC(=O)C[N+]1(CCC(C1)OC(=O)C(C2CCCC2)(C3=CC=CC=C3)O)C.[Br-] |
| Reference | </br>1:Effect of acute and long term potassium bromide administration on spatial working memory in rat. Safdari F, Rabbani M, Hosseini-Sharifabad A.Res Pharm Sci. 2017 Apr;12(2):154-159. doi: 10.4103/1735-5362.202454. PMID: 28515768 </br>2:Headspace single-drop microextraction coupled with microvolume fluorospectrometry for highly sensitive determination of bromide. García-Figueroa A, Pena-Pereira F, Lavilla I, Bendicho C.Talanta. 2017 Aug 1;170:9-14. doi: 10.1016/j.talanta.2017.03.090. Epub 2017 Mar 30. PMID: 28501219 </br>3:Enhanced pseudocapacitive performance of electroactive p-type conductive polymer in the presence of 1-octadecyl-3-methylimidazolium bromide. Ehsani A, Kowsari E, Dashti Najafi M, Safari R, Mohammad Shiri H.J Colloid Interface Sci. 2017 May 4;503:10-16. doi: 10.1016/j.jcis.2017.05.008. [Epub ahead of print] PMID: 28500935 </br>4:Vibrational spectroscopic and computational studies on diisopropylammonium bromide. Sahoo S, Ravindran TR, Chandra S, Sarguna RM, Das BK, Sairam TN, Sivasubramanian V, Thirmal C, Murugavel P.Spectrochim Acta A Mol Biomol Spectrosc. 2017 May 5;184:211-219. doi: 10.1016/j.saa.2017.05.006. [Epub ahead of print] PMID: 28499175 </br>5:Practical Method for the Catalytic Enantioselective Arylation and Heteroarylation of Ketones with Organotitanium Reagents Generated in situ from Bromide and Heteroarene Precursors. Matsuda A, Ushimaru T, Kobayashi Y, Harada T.Chemistry. 2017 May 12. doi: 10.1002/chem.201701395. [Epub ahead of print] PMID: 28497884 </br>6:Catalytic dehydrogenative dual functionalization of ethers: dealkylation-oxidation-bromination accompanied by C-O bond cleavage via aerobic oxidation of bromide. Moriyama K, Hamada T, Nakamura Y, Togo H.Chem Commun (Camb). 2017 May 12. doi: 10.1039/c7cc02166f. [Epub ahead of print] PMID: 28497153 </br>7:Cation Dynamics in Supercooled and Solid Alkyl Methylimidazolium Bromide Ionic Liquids. Ordikhani Seyedlar A, Stapf S, Mattea C.J Phys Chem B. 2017 May 19. doi: 10.1021/acs.jpcb.7b01712. [Epub ahead of print] PMID: 28485936 </br>8:Influences of cisatracurium besylate and vecuronium bromide on muscle relaxant effects and electromyography of tracheal intubation under general anesthesia. Yu DJ, Gao HY.Eur Rev Med Pharmacol Sci. 2017 Apr;21(8):1974-1979. PMID: 28485777 Free Article</br>9:The evidence on tiotropium bromide in asthma: from the rationale to the bedside. Radovanovic D, Santus P, Blasi F, Mantero M.Multidiscip Respir Med. 2017 May 4;12:12. doi: 10.1186/s40248-017-0094-3. eCollection 2017. Review. PMID: 28484598 Free PMC Article</br>10:The antifungal effects and mechanical properties of silver bromide/cationic polymer nano-composite-modified Poly-methyl methacrylate-based dental resin. Zhang Y, Chen YY, Huang L, Chai ZG, Shen LJ, Xiao YH.Sci Rep. 2017 May 8;7(1):1547. doi: 10.1038/s41598-017-01686-4. PMID: 28484255 Free PMC Article |
