For research use only. Not for therapeutic Use.
Sonlicromanol (KH176) hydrochloride, a chemical entity derivative of Trolox, is a blood-brain barrier permeable ROS-redox modulator. Sonlicromanol (KH176) hydrochloride is used in the study for mitochondrial disorders[1].
Sonlicromanol (KH176) hydrochloride maintains microstructural coherence in the brain of Ndufs4−/− mice[1].
| Catalog Number | I045539 |
| CAS Number | 2162149-24-6 |
| Synonyms | (2S)-6-hydroxy-2,5,7,8-tetramethyl-N-[(3R)-piperidin-3-yl]-3,4-dihydrochromene-2-carboxamide;hydrochloride |
| Molecular Formula | C19H29ClN2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H28N2O3.ClH/c1-11-12(2)17-15(13(3)16(11)22)7-8-19(4,24-17)18(23)21-14-6-5-9-20-10-14;/h14,20,22H,5-10H2,1-4H3,(H,21,23);1H/t14-,19+;/m1./s1 |
| InChIKey | HVFWCHDZDIRYBZ-MQZJHDQISA-N |
| SMILES | CC1=C(C2=C(CCC(O2)(C)C(=O)NC3CCCNC3)C(=C1O)C)C.Cl |
| Reference | [1]. Ria de Haas, et al. Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease. Sci Rep. 2017 Sep 15;7(1):11733. |
