For research use only. Not for therapeutic Use.
Sonlicromanol (KH176) is an orally active reactive oxygen species (ROS) modulator for the study in mitochondrial disease[1][2].
Sonlicromanol (KH176, 10 mg/kg, ip, twice daily) has promising, but independent and nonadditive, properties for the pharmacological treatment of CI-deficiency-related mitochondrial diseases[3].
| Catalog Number | I007499 |
| CAS Number | 1541170-75-5 |
| Synonyms | (2S)-6-hydroxy-2,5,7,8-tetramethyl-N-[(3R)-piperidin-3-yl]-3,4-dihydrochromene-2-carboxamide |
| Molecular Formula | C19H28N2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H28N2O3/c1-11-12(2)17-15(13(3)16(11)22)7-8-19(4,24-17)18(23)21-14-6-5-9-20-10-14/h14,20,22H,5-10H2,1-4H3,(H,21,23)/t14-,19+/m1/s1 |
| InChIKey | LZYWLEPSQNXESC-KUHUBIRLSA-N |
| SMILES | CC1=C(C2=C(CCC(O2)(C)C(=O)NC3CCCNC3)C(=C1O)C)C |
| Reference | [1]. X Jiang, et al. Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE 2 biosynthesis by sonlicromanol’s metabolite KH176m. Sci Rep. 2021 Jan 13;11(1):880. [2]. Zikai Feng, et al. Comparative In Vitro Toxicology of Novel Cytoprotective Short-Chain Naphthoquinones. Pharmaceuticals (Basel). 2020 Aug 7;13(8):184. [3]. Sanne J C M Frambach, et al. Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice. Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165727. |
