For research use only. Not for therapeutic Use.
SOP1812 is a novel quadruplex ligand, down-regulating several cancer gene pathways, including Wnt/β-catenin signaling, showing potent activity in pancreatic cancer models.
| Catalog Number | I036506 |
| Synonyms | SOP1812; SOP 1812; SOP-1812; |
| Molecular Formula | C45H58N8O6 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2,7-bis(3-morpholinopropyl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)-9-((4-(pyrrolidin-1-ylmethyl)phenyl)amino)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone |
| InChI | InChI=1S/C45H58N8O6/c54-42-34-29-36(46-11-20-48-12-1-2-13-48)40-38-35(43(55)52(44(40)56)18-5-16-49-21-25-58-26-22-49)30-37(47-33-9-7-32(8-10-33)31-51-14-3-4-15-51)41(39(34)38)45(57)53(42)19-6-17-50-23-27-59-28-24-50/h7-10,29-30,46-47H,1-6,11-28,31H2 |
| InChIKey | KTGDGRJNPRWCFQ-UHFFFAOYSA-N |
| SMILES | O=C(N(CCCN1CCOCC1)C2=O)C3=C(NC4=CC=C(CN5CCCC5)C=C4)C=C6C7=C3C2=CC(NCCN8CCCC8)=C7C(N(CCCN9CCOCC9)C6=O)=O |
| Reference | 1: Ahmed AA, Angell R, Oxenford S, Worthington J, Williams N, Barton N, Fowler TG, O’Flynn DE, Sunose M, McConville M, Vo T, Wilson WD, Karim SA, Morton JP, Neidle S. Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models. ACS Med Chem Lett. 2020 Jul 16;11(8):1634-1644. doi: 10.1021/acsmedchemlett.0c00317. PMID: 32832034; PMCID: PMC7429975. |
