Sophocarpine

• CAT Number: R015776
• CAS Number: 6483-15-4
• Molecular Formula: C15H22N2O
• Molecular Weight: 246.354
• Purity: ≥95%
• Target: Apoptosis
• Storage: 3 years -20C powder
• InChI: InChI=1S/C15H22N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h1,7,11-13,15H,2-6,8-10H2/t11-,12+,13+,15-/m0/s1
• InChIKey: AAGFPTSOPGCENQ-JLNYLFASSA-N
• SMILES: C1CC2CN3C(CC=CC3=O)C4C2N(C1)CCC4

Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages.Administration of 50 mg/kg/d sophocarpine for 5 days from the onset of cachexia does not inhibit the tumor growth but results in attenuation of cachexia symptoms in colon26 adenocarcinoma xenograft BALB/c mice.