For research use only. Not for therapeutic Use.
Sorbinil, also known as CP-45634, is an aldose reductase inhibitor potentially for the treatment of diabetes. Aldose reductase is an enzyme present in lens and brain that gets rid of excess glucose by converting it to sorbitol. Sorbitol accumulation can lead to the development of cataracts in the lens and neuropathy in peripheral nerves. Sorbinil has been shown to inhibit aldose reductase in human brain and placenta and calf and rat lens. Sorbinil reduced sorbitol accummulation in rat lens and sciatic nerve of diabetic rats orally administered 0.25mg/kg sorbinil.
| Catalog Number | I009562 |
| CAS Number | 68367-52-2 |
| Synonyms | Sorbinil; CP-45634; CP 45634; CP45634.;(S)-6-fluorospiro[chromane-4,4/’-imidazolidine]-2/’,5/’-dione |
| Molecular Formula | C11H9FN2O3 |
| Purity | ≥95% |
| Target | Aldose Reductase |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | (4S)-6-fluorospiro[2,3-dihydrochromene-4,5/'-imidazolidine]-2/',4/'-dione |
| InChI | InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1 |
| InChIKey | LXANPKRCLVQAOG-NSHDSACASA-N |
| SMILES | C1COC2=C(C13C(=O)NC(=O)N3)C=C(C=C2)F |
| Reference | </br>1:Effect of treating streptozotocin-induced diabetic rats with sorbinil, myo-inositol or aminoguanidine on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve. Coppey LJ, Gellett JS, Davidson EP, Dunlap JA, Yorek MA.Int J Exp Diabetes Res. 2002;3(1):21-36. PMID: 11900277 Free PMC Article</br>2:The effect of sorbinil, an aldose reductase inhibitor, on aortic function in control and streptozotocin-induced diabetic rats. Sellers DJ, Chess-Williams R.J Auton Pharmacol. 2000 Feb;20(1):15-22. PMID: 11048957 </br>3:The sorbinil trap: a predicted dead-end complex confirms the mechanism of aldose reductase inhibition. Bohren KM, Grimshaw CE.Biochemistry. 2000 Aug 15;39(32):9967-74. PMID: 10933817 </br>4:The effects of streptozotocin-induced diabetes and aldose reductase inhibition with sorbinil, on left and right atrial function in the rat. Sellers DJ, Chess-Williams R.J Pharm Pharmacol. 2000 Jun;52(6):687-94. PMID: 10875546 </br>5:Risk factors for progression of distal symmetric polyneuropathy in type 1 diabetes mellitus. Sorbinil Retinopathy Trial Research Group. Christen WG, Manson JE, Bubes V, Glynn RJ.Am J Epidemiol. 1999 Dec 1;150(11):1142-51. PMID: 10588075 </br>6:Effect of sorbinil and ascorbic acid on myo-inositol transport in cultured rat Schwann cells exposed to elevated extracellular glucose. Karihaloo AK, Joshi K, Chopra JS.J Neurochem. 1997 Nov;69(5):2011-8. PMID: 9349546 Free Article</br>7:A /’specificity/’ pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil. Urzhumtsev A, Tête-Favier F, Mitschler A, Barbanton J, Barth P, Urzhumtseva L, Biellmann JF, Podjarny A, Moras D.Structure. 1997 May 15;5(5):601-12. PMID: 9195881 </br>8:Comparison of the effects of Zopolrestat and Sorbinil on lens myo-inositol influx. Beyer-Mears A, Diecke FP, Mistry K, Cruz E.Pharmacology. 1997 Feb;54(2):76-83. PMID: 9088040 </br>9:The aldose reductase inhibitor sorbinil does not prevent the impairment in nitric oxide-mediated neurotransmission in anococcygeus muscle from diabetic rats. Way KJ, Reid JJ.Eur J Pharmacol. 1996 Dec 27;318(1):101-8. PMID: 9007520 </br>10:The effects of acetyl-L-carnitine and sorbinil on peripheral nerve structure, chemistry, and function in experimental diabetes. Malone JI, Lowitt S, Salem AF, Miranda C, Korthals JK, Carver J.Metabolism. 1996 Jul;45(7):902-7. PMID: 8692029 |
