Sorbinil

• CAT Number: I009562
• CAS Number: 68367-52-2
• Molecular Formula: C11H9FN2O3
• Molecular Weight: 236.20
• Purity: ≥95%
• Synonyms: Sorbinil; CP-45634; CP 45634; CP45634.;(S)-6-fluorospiro[chromane-4,4/’-imidazolidine]-2/’,5/’-dione
• Target: Aldose Reductase
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: (4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione
• InChI: InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1
• InChIKey: LXANPKRCLVQAOG-NSHDSACASA-N
• SMILES: C1COC2=C([C@]13C(=O)NC(=O)N3)C=C(C=C2)F

Sorbinil（Cat No.:I009562）is an experimental drug that functions as an inhibitor of aldose reductase, an enzyme involved in the polyol pathway, which plays a role in the complications of diabetes, particularly diabetic neuropathy and cataracts. By inhibiting aldose reductase, Sorbinil aims to prevent the accumulation of sorbitol, a sugar alcohol that contributes to cellular damage when it builds up in tissues like the eyes, nerves, and kidneys. Sorbinil has been studied for its potential to reduce complications associated with diabetes, though its clinical use has been limited, with ongoing research focusing on its effectiveness and safety.