Sortilin antagonist 1

• CAT Number: I041769
• CAS Number: 2691846-93-0
• Molecular Formula: C20H24N2O4
• Molecular Weight: 356.42
• Purity: ≥95%
• Synonyms: (2S)-5,5-dimethyl-2-[(6-phenoxypyridine-3-carbonyl)amino]hexanoic acid
• InChI: InChI=1S/C20H24N2O4/c1-20(2,3)12-11-16(19(24)25)22-18(23)14-9-10-17(21-13-14)26-15-7-5-4-6-8-15/h4-10,13,16H,11-12H2,1-3H3,(H,22,23)(H,24,25)/t16-/m0/s1
• InChIKey: OWESOSHRVQOBOS-INIZCTEOSA-N
• SMILES: CC(C)(C)CCC(C(=O)O)NC(=O)C1=CN=C(C=C1)OC2=CC=CC=C2

Sortilin antagonist 1 (compound 44) is a sortilin antagonist with an IC50 value of 20 nM for inhibiting Neurotensin (NTS) binds to sortilin. Neurotensin is a sortilin ligand. Sortilin antagonist 1 can be used for the research of neurological disease[1].

Reference

[1]. Kjoelby, Mads Fuglsang, et al. A sortilin antagonist for use in the prevention or treatment of hearing loss. WO2022074119. 2022.