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959-24-0-Sotalol Hydrochloride Sotalol Hydrochloride

Sotalol Hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: A000433
  • CAS Number: 959-24-0
  • Molecular Formula: C12H21ClN2O3S
  • Molecular Weight: 308.8
  • Purity: ≥95%
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Related Small Molecules: Methylthiouracil     Zanamivir     Rizatriptan Benzoate    

Sotalol hydrochloride is an adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.Sotalol hydrochloride is a compound categorized with class III antiarrhythmic activity with a mechanism of action that prolongs the action potential and refraction of cardiac tissue through non-selective yet potent β-adronergic blocking activity.


Catalog Number A000433
CAS Number 959-24-0
Synonyms

959-24-0; Sotalol HCL; Betapace; Betapace AF; Sotacor

Molecular Formula C12H21ClN2O3S
Purity ≥95%
Target β Adrenergic Antagonist
Storage -20°C
InChI 1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
InChIKey VIDRYROWYFWGSY-UHFFFAOYSA-N
SMILES CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.Cl
Reference

1: Broux B, De Clercq D, Decloedt A, Vera L, Devreese M, Gehring R, Croubels S,
van Loon G. Pharmacokinetics and electrophysiological effects of sotalol
hydrochloride in horses. Equine Vet J. 2017 Oct 10. doi: 10.1111/evj.12765. [Epub
ahead of print] PubMed PMID: 29023952.
<br>

2: Broux B, De Clercq D, Decloedt A, De Baere S, Devreese M, Van Der Vekens N,
Ven S, Croubels S, van Loon G. Pharmacokinetics of intravenously and orally
administered sotalol hydrochloride in horses and effects on surface
electrocardiogram and left ventricular systolic function. Vet J. 2016
Feb;208:60-4. doi: 10.1016/j.tvjl.2015.09.021. Epub 2015 Oct 1. PubMed PMID:
26670333.

<br>
3: Sidhom MB, Rivera N, Almoazen H, Taft DR, Kirschenbaum HL. Stability of
sotalol hydrochloride in extemporaneously prepared oral suspension formulations.
Int J Pharm Compd. 2005 Sep-Oct;9(5):402-6. PubMed PMID: 23925139.

<br>
4: Wang WH, Zhao GS, Jiang WL, Zuo AX, Bi HT. [Determination of sotalol
hydrochloride by reversed-phase high performance liquid chromatography]. Se Pu.
2000 Mar;18(2):178-80. Chinese. PubMed PMID: 12541604.
<br>

5: Telichowski A, Banasiak W, Wiech K, Zeborowski J, Pieróg M, Ponikowski P,
Ka&#322;ka D, Lacheta W, Fuglewicz A, Telichowski C. [The effect of sotalol
hydrochloride therapy on atrial signal-averaged ECG in patients with paroxysmal
atrial fibrillation]. Pol Merkur Lekarski. 1996 Nov;1(5):303-9. Polish. PubMed
PMID: 9273201.
<br>

6: Bobak J, Banasiak W, Telichowski A, Ponikowski P, Ka&#322;ka D, Jagielski J,
Telichowski C. [The effects of long-term treatment of sotalol hydrochloride on
time and frequency domain parameters of signal averaged electrocardiogram in
patients with ischemic heart disease]. Pol Arch Med Wewn. 1996 Apr;95(4):289-98.
Polish. PubMed PMID: 8755834.

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7: Herrmann R, Kleinbloesem CH. [Testing of bioequivalence of a new sotalol
hydrochloride preparation in comparison to a standard formulation].
Arzneimittelforschung. 1995 Aug;45(8):849-52. German. PubMed PMID: 7575745.
<br>

8: Herrmann R, Kleinbloesem CH. [Bioequivalence of a new tablet formulation of
sotalol hydrochloride in comparison to a standard preparations].
Arzneimittelforschung. 1994 May;44(5):589-92. German. PubMed PMID: 8024627.

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9: Porterfield JG, Porterfield LM. Sotalol hydrochloride (Betapace): a new
antiarrhythmic drug. Am J Crit Care. 1994 Jan;3(1):80. PubMed PMID: 8118498.

<br>
10: Dunnington CS. Sotalol hydrochloride (Betapace): a new antiarrhythmic drug.
Am J Crit Care. 1993 Sep;2(5):397-406. Review. PubMed PMID: 8220672.

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