SOTS-1 (technical grade)

• CAT Number: R027578
• CAS Number: 223507-96-8
• Molecular Formula: C16H14N2O6
• Molecular Weight: 330.296
• Purity: ≥95%
• Synonyms: Superoxide Thermal Source;Di-(4-Carboxybenzyl)Hyponitrite
• Storage: -80°C
• IUPAC Name: 4-[[(4-carboxyphenyl)methoxydiazenyl]oxymethyl]benzoic acid
• InChI: InChI=1S/C16H14N2O6/c19-15(20)13-5-1-11(2-6-13)9-23-17-18-24-10-12-3-7-14(8-4-12)16(21)22/h1-8H,9-10H2,(H,19,20)(H,21,22)
• InChIKey: KNKCXZHPOIMNJH-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1CON=NOCC2=CC=C(C=C2)C(=O)O)C(=O)O

Superoxide radical anion is a toxic by-<wbr></wbr>product of mitochondrial respiration that is formed from approximately 1-<wbr></wbr>4% of the oxygen metabolized by aerobic organisms. SOTS-<wbr></wbr>1 is an azo-<wbr></wbr>compound that can be thermally decomposed in aqueous solution to generate superoxide radical anion at a constant, controlled rate. More specifically, SOTS-<wbr></wbr>1 thermally decomposes to form an intermediate that reacts with oxygen at the diffusion-<wbr></wbr>controlled limit to generate superoxide radical anion. The decay of SOTS-<wbr></wbr>1 into the intermediate follows first order kinetics, and exhibits a half-<wbr></wbr>life of 4900 seconds at physiological pH and temperature. This allows for study of the effect of superoxide on biologically relevant systems in a controlled environment that closely mimics conditions in vivo.

Reference

1.Konya, K.G.,Paul, T.,Lin, S., et al. Laser flash photolysis studies on the first superoxide thermal source. First direct measurements of the rates of solvent-assisted 1,2-hydrogen atom shifts and a proposed new mechanism for this unusual rearrangement.