For research use only. Not for therapeutic Use.
SP-187（Cat No.:I009566）is a synthetic peptide known for its potent antimicrobial activity, particularly against antibiotic-resistant bacterial strains. Developed to mimic natural host defense peptides, SP-187 works by disrupting bacterial cell membranes, leading to rapid bacterial cell death. Its mechanism minimizes the likelihood of developing resistance, making it a promising candidate in the fight against multidrug-resistant pathogens. With a broad spectrum of activity and minimal toxicity to mammalian cells, SP-187 is under investigation for therapeutic applications in treating severe infections, especially in hospital and clinical research settings.
| Catalog Number | I009566 |
| CAS Number | 615253-61-7 |
| Synonyms | SP-187; SP187; SP 187; N-9-DNJ; UV-4B; N9DNJ; UV4B; N 9 DNJ; UV 4B;(2R,3R,4R,5S)-2-(hydroxymethyl)-1-(9-methoxynonyl)piperidine-3,4,5-triol |
| Molecular Formula | C16H33NO5 |
| Purity | ≥95% |
| Target | alpha-Glucosidase Inhibitor |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | (2R,3R,4R,5S)-2-(hydroxymethyl)-1-(9-methoxynonyl)piperidine-3,4,5-triol |
| InChI | InChI=1S/C16H33NO5/c1-22-10-8-6-4-2-3-5-7-9-17-11-14(19)16(21)15(20)13(17)12-18/h13-16,18-21H,2-12H2,1H3/t13-,14+,15-,16-/m1/s1 |
| InChIKey | TYTARGBBJQKLAJ-QKPAOTATSA-N |
| SMILES | COCCCCCCCCCN1C[C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O |
| Reference | </br>1:Sugiura M, Kisumi M. Proline-hyperproducing strains of Serratia marcescens: enhancement of proline analog-mediated growth inhibition by increasing osmotic stress. Appl Environ Microbiol. 1985 Apr;49(4):782-6. PubMed PMID: 2860849; PubMed Central PMCID: PMC238445.</br>2:Baba E, Nakamura M, Ohkuma K, Kira J, Tanaka Y, Nakano S, Niho Y. A peptide-based human T cell leukemia virus type I vaccine containing T and B cell epitopes that induces high titers of neutralizing antibodies. J Immunol. 1995 Jan 1;154(1):399-412. PubMed PMID: 7527817. |
