Sp-5,6-dichloro-cBIMPS (sodium salt)

• CAT Number: I011742
• CAS Number: 142439-96-1
• Molecular Formula: C12H10Cl2N2O5PS • Na
• Molecular Weight: 419.18
• Purity: ≥95%
• Synonyms: 5,6-dichloro-1-[3,5-O-[(S)-mercaptophosphinylidene]-β-D-ribofuranosyl]-1H-benzimidazole, monosodium salt
• Target: PKA
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: sodium;(4aR,6R,7R,7aS)-6-(5,6-dichlorobenzimidazol-1-yl)-2-oxido-2-sulfanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
• InChI: InChI=1S/C12H11Cl2N2O5PS.Na/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-10(17)11-9(20-12)3-19-22(18,23)21-11;/h1-2,4,9-12,17H,3H2,(H,18,23);/q;+1/p-1/t9-,10-,11-,12-,22?;/m1./s1
• InChIKey: LXTHVPHQPNCKKG-OIMJWDEGSA-M
• SMILES: C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=CC(=C(C=C43)Cl)Cl)O)OP(=S)(O1)[O-].[Na+]

Sp-5,6-dichloro-cBIMPS (sodium salt)(CAT: I011742) is a potent and selective activator of cyclic AMP (cAMP)-dependent protein kinase (PKA). This compound mimics the effects of cAMP by binding to the regulatory subunits of PKA, leading to activation of the kinase and subsequent phosphorylation of downstream targets. It is particularly valuable in cell signaling and neuroscience research, supporting studies on cAMP/PKA pathways involved in cellular proliferation, differentiation, and memory formation. Sp-5,6-dichloro-cBIMPS (sodium salt) is a reliable tool for dissecting the molecular mechanisms of PKA signaling and exploring its therapeutic implications in diseases such as cancer and neurodegenerative disorders.