SP-8008

• CAT Number: I047646
• CAS Number: 2088247-61-2
• Molecular Formula: C15H14O6
• Molecular Weight: 290.27
• Purity: ≥95%
• IUPAC Name: (2-ethyl-4-oxopyran-3-yl) 4-hydroxy-3-methoxybenzoate
• InChI: InChI=1S/C15H14O6/c1-3-12-14(11(17)6-7-20-12)21-15(18)9-4-5-10(16)13(8-9)19-2/h4-8,16H,3H2,1-2H3
• SMILES: CCC1=C(C(=O)C=CO1)OC(=O)C2=CC(=C(C=C2)O)OC

SP-8008 is a potent and selective inhibitor of SIPA with an IC50 value of 1.44 μM. Moreover, SP-8008 is a modulator of vWF-GP Ib interactions. Importantly, SP-8008 exerted significant antithrombotic effects in vivo in both shear stress-specific and arterial thrombosis, without prolonging bleeding time.
KEYWORDS: SP-8008 | supplier | SIPA inhibitor | SP 8008 | SP8008 | CAS [2088247-61-2] | SIPA | SIPA | vWF | GP Ib | Inhibitor | Receptors | Antiplatelet | Antithrombotic

Reference

T Ngo et al. Antithrombotic effect of SP-8008, a benzoic acid derivative, through the selective inhibition of shear stress-induced platelet aggregation. Br J Pharmacol. 2020 Feb;177(4):929-944.