For research use only. Not for therapeutic Use.
SP600125（Cat No.:I001134）is a selective inhibitor of c-Jun N-terminal kinase (JNK), a key component of the MAPK signaling pathway involved in cellular responses to stress, inflammation, and apoptosis. By inhibiting JNK, SP600125 blocks the phosphorylation of c-Jun, preventing the activation of transcription factors that regulate pro-inflammatory and apoptotic genes. It has been widely used in research to study the role of JNK in various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions. SP600125 is a valuable tool for investigating the therapeutic potential of targeting JNK in disease models.
| Catalog Number | I001134 |
| CAS Number | 129-56-6 |
| Synonyms | dibenzo[cd,g]indazol-6(2H)-one |
| Molecular Formula | C₁₄H₈N₂O |
| Purity | ≥95% |
| Target | JNK |
| Solubility | DMSO: ≥ 45 mg/mL |
| Storage | 3 years -20C powder |
| IC50 | 40/40/90 nM(JNK1/2/3) |
| IUPAC Name | 14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9(16),10,12-heptaen-8-one |
| InChI | InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) |
| InChIKey | ACPOUJIDANTYHO-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O |
| Reference | </br>1:JNK Inhibitor SP600125 Attenuates Paraquat-Induced Acute Lung Injury: an In Vivo and In Vitro Study. Shen H, Wu N, Wang Y, Han X, Zheng Q, Cai X, Zhang H, Zhao M.Inflammation. 2017 May 4. doi: 10.1007/s10753-017-0575-8. [Epub ahead of print] PMID: 28474156 </br>2:Effect of SP600125 on the mitotic spindle in HeLa Cells, leading to mitotic arrest, endoreduplication and apoptosis. Mili D, Abid K, Rjiba I, Kenani A.Mol Cytogenet. 2016 Nov 25;9:86. eCollection 2016. PMID: 27924151 Free PMC Article</br>3:SP600125 Attenuates Nicotine-Related Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase Production and CC Chemokine-Mediated Macrophage Migration. Guo ZZ, Cao QA, Li ZZ, Liu LP, Zhang Z, Zhu YJ, Chu G, Dai QY.Mediators Inflamm. 2016;2016:9142425. Epub 2016 Sep 1. PMID: 27688602 Free PMC Article</br>4:[SP600125-induced polyploidization of megakaryocytic leukemia cell lines by ribosomal protein S6 kinase 1 depends on the degree of cell differentiation]. Wang L, Yang J, Li C, Xing S, Yu Y, Liu S, Zhao S, Ma D.Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Oct;32(10):1336-1341. Chinese. PMID: 27667458 </br>5:[Protein kinase A inhibitor H-89 blocks polyploidization of SP600125-induced CMK cells by regulating phosphorylation of ribosomal protein S6 kinase 1]. Zhao S, Yang J, Li C, Xing S, Yu Y, Liu S, Pu F, Ma D.Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Oct;32(10):1321-1326. Chinese. PMID: 27667455 </br>6:Effect of JNK inhibitor SP600125 on hair cell regeneration in zebrafish (Danio rerio) larvae. He Y, Cai C, Sun S, Wang X, Li W, Li H.Oncotarget. 2016 Aug 9;7(32):51640-51650. doi: 10.18632/oncotarget.10540. PMID: 27438150 Free PMC Article</br>7:SP600125 enhances the anti-apoptotic capacity and migration of bone marrow mesenchymal stem cells treated with tumor necrosis factor-α. Wei B, Bai X, Chen K, Zhang X.Biochem Biophys Res Commun. 2016 Jul 8;475(4):301-7. doi: 10.1016/j.bbrc.2016.05.107. Epub 2016 May 24. PMID: 27233606 </br>8:Autotetraploid cell line induced by SP600125 from crucian carp and its developmental potentiality. Zhou Y, Wang M, Jiang M, Peng L, Wan C, Liu J, Liu W, Zhao R, Zhao X, Hu W, Liu S, Xiao Y.Sci Rep. 2016 Feb 22;6:21814. doi: 10.1038/srep21814. PMID: 26898354 Free PMC Article</br>9:SP600125 has a remarkable anticancer potential against undifferentiated thyroid cancer through selective action on ROCK and p53 pathways. Grassi ES, Vezzoli V, Negri I, Lábadi Á, Fugazzola L, Vitale G, Persani L.Oncotarget. 2015 Nov 3;6(34):36383-99. doi: 10.18632/oncotarget.5799. PMID: 26415230 Free PMC Article</br>10:SP600125 promotes resolution of allergic airway inflammation via TLR9 in an OVA-induced murine acute asthma model. Wu HM, Fang L, Shen QY, Liu RY.Mol Immunol. 2015 Oct;67(2 Pt B):311-6. doi: 10.1016/j.molimm.2015.06.016. Epub 2015 Jun 29. PMID: 26139014 |
