For research use only. Not for therapeutic Use.
SPA70 is a potent and selective antagonist of human pregnane X receptor (hPXR), with an IC50 of 540 nM (Ki=390 nM). SPA70 can enhance the chemosensitivity of cancer cells[1].
| Catalog Number | I044358 |
| CAS Number | 931314-31-7 |
| Synonyms | 4-(4-tert-butylphenyl)sulfonyl-1-(2,5-dimethoxyphenyl)-5-methyltriazole |
| Molecular Formula | C21H25N3O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C21H25N3O4S/c1-14-20(29(25,26)17-10-7-15(8-11-17)21(2,3)4)22-23-24(14)18-13-16(27-5)9-12-19(18)28-6/h7-13H,1-6H3 |
| InChIKey | OIOPHIFJQXHPAF-UHFFFAOYSA-N |
| SMILES | CC1=C(N=NN1C2=C(C=CC(=C2)OC)OC)S(=O)(=O)C3=CC=C(C=C3)C(C)(C)C |
| Reference | [1]. Lin W, et, al. SPA70 is a potent antagonist of human pregnane X receptor. Nat Commun. 2017 Sep 29;8(1):741. |
