SPAA-52

• CAT Number: I042706
• CAS Number: 2837000-75-4
• Molecular Formula: C8H8Br2N2O4S
• Molecular Weight: 388.03
• Purity: ≥95%
• Synonyms: (3,5-dibromo-4-methylphenyl)carbamoylsulfamic acid
• InChI: InChI=1S/C8H8Br2N2O4S/c1-4-6(9)2-5(3-7(4)10)11-8(13)12-17(14,15)16/h2-3H,1H3,(H2,11,12,13)(H,14,15,16)
• InChIKey: XBWKZLBEUSPLFY-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1Br)NC(=O)NS(=O)(=O)O)Br

SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC50=4 nM, Ki=1.2 nM). SPAA-52 can be used in diabete research[1].
1.19

Plasma PK Parameters in Healthy Mice[1]

Compound
SPAA-52

dose route
2 mg/kg IV
10 mg/kg PO

AUC (0−8 h) (nM h)
15,100
37,300

C0 or Cmax (nM)
13,400
9690

C0 or Cmax unbound (nM)
332
233

Vdss (L/kg)
0.42

CL (mL/min/kg)
5.65

T1/2 (h)
1.41
4.2

F (%)

34

1.19

Plasma PK Parameters in Healthy Rats[1]

Compound
SPAA-52

dose route
3 mg/kg PO

AUC (0-12 h) (nM h)
4660

Cmax (nM)
877

Cmax unbound (nM)
21

Vdss (L/kg)
0.42

Tmax (h)
2.0

T1/2 (h)
2.4

Reference

[1]. He R, et al. Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors. J Med Chem. 2022 Oct 5.
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