For research use only. Not for therapeutic Use.
(+)-sparteine (sulfate pentahydrate) is a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons[1].
(+)-Sparteine (2 μM) (sulfate pentahydrate) reduces the ACh-induced current caused by activation of nicotinic ACh receptors (AChRs) in a voltage-independent manner at membrane potentials of -50 mV to +30 mV, whereas its blocking effect increased at more negative membrane potentials. (+)-sparteine (5 μM and 10 μM) (sulfate pentahydrate) reduces the amplitude of the excitatory postsynaptic currents (EPSC) and the time constant of the EPSC decay[1].
| Catalog Number | I045019 |
| Synonyms | (1R,2S,9R,10R)-7,15-diazatetracyclo[7.7.1.02,7.010,15]heptadecane;sulfuric acid;pentahydrate |
| Molecular Formula | C15H38N2O9S |
| Purity | ≥95% |
| InChI | InChI=1S/C15H26N2.H2O4S.5H2O/c1-3-7-16-11-13-9-12(14(16)5-1)10-17-8-4-2-6-15(13)17;1-5(2,3)4;;;;;/h12-15H,1-11H2;(H2,1,2,3,4);5*1H2/t12-,13-,14-,15+;;;;;;/m1....../s1 |
| InChIKey | WNSDDGBLIALDPB-HTZKOJAYSA-N |
| SMILES | C1CCN2CC3CC(C2C1)CN4C3CCCC4.O.O.O.O.O.OS(=O)(=O)O |
| Reference | [1]. Voitenko S, et al. Effect of (+)-sparteine on nicotinic acetylcholine receptors in the neurons of rat superior cervical ganglion. |
