For research use only. Not for therapeutic Use.
Spastazoline is an effective, selective inhibitor of amicrotubule-severing AAA ( ATPases associated withdiverse cellular activities ) protein, with IC50value of99nM for human spastin. Spastazoline did not inhibit the ATPase activity of recombinant human VPS4 ( another AAA protein required for intercellular bridge disassembly ).
| Catalog Number | I019506 |
| CAS Number | 2351882-11-4 |
| Molecular Formula | C₂₀H₃₀N₈ |
| Purity | ≥95% |
| Storage | Store at -20°C |
| IUPAC Name | N-(5-tert-butyl-1H-pyrazol-3-yl)-2-[(3R)-3-propan-2-ylpiperazin-1-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| InChI | InChI=1S/C20H30N8/c1-12(2)14-11-28(9-8-21-14)19-24-17-13(6-7-22-17)18(25-19)23-16-10-15(26-27-16)20(3,4)5/h6-7,10,12,14,21H,8-9,11H2,1-5H3,(H3,22,23,24,25,26,27)/t14-/m0/s1 |
| InChIKey | HNOLTAKAPDKZRY-AWEZNQCLSA-N |
| SMILES | CC(C)C1CN(CCN1)C2=NC3=C(C=CN3)C(=N2)NC4=NNC(=C4)C(C)(C)C |
| Reference | [1]. Cupido T, et al. Designing a chemical inhibitor for the AAA protein spastin using active site mutations. Nat Chem Biol. 2019 Feb 18. |
