Spastazoline

• CAT Number: I019506
• CAS Number: 2351882-11-4
• Molecular Formula: C₂₀H₃₀N₈
• Molecular Weight: 382.51
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: N-(5-tert-butyl-1H-pyrazol-3-yl)-2-[(3R)-3-propan-2-ylpiperazin-1-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• InChI: InChI=1S/C20H30N8/c1-12(2)14-11-28(9-8-21-14)19-24-17-13(6-7-22-17)18(25-19)23-16-10-15(26-27-16)20(3,4)5/h6-7,10,12,14,21H,8-9,11H2,1-5H3,(H3,22,23,24,25,26,27)/t14-/m0/s1
• InChIKey: HNOLTAKAPDKZRY-AWEZNQCLSA-N
• SMILES: CC(C)C1CN(CCN1)C2=NC3=C(C=CN3)C(=N2)NC4=NNC(=C4)C(C)(C)C

Spastazoline is an effective, selective inhibitor of amicrotubule-severing AAA ( ATPases associated withdiverse cellular activities ) protein, with IC50value of99nM for human spastin. Spastazoline did not inhibit the ATPase activity of recombinant human VPS4 ( another AAA protein required for intercellular bridge disassembly ).

Reference

[1]. Cupido T, et al. Designing a chemical inhibitor for the AAA protein spastin using active site mutations. Nat Chem Biol. 2019 Feb 18.