For research use only. Not for therapeutic Use.
Spautin-1 (Cat.No:I001061) is a chemical compound known for its autophagy-modulating properties. It inhibits the activity of USP10 and USP13, deubiquitinases involved in autophagy regulation. By inhibiting these enzymes, Spautin-1 promotes autophagic degradation and has shown potential in preclinical studies for the treatment of neurodegenerative diseases and cancer.
| Catalog Number | I001061 |
| CAS Number | 1262888-28-7 |
| Synonyms | (Z)-1-(4-fluorophenyl)-N-(6-fluoroquinazolin-4(3H)-ylidene)methanamine |
| Molecular Formula | C₁₅H₁₁F₂N₃ |
| Purity | ≥95% |
| Target | Autophagy |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | (1.03 μM, IM for K562 cell; 0.45 μM, Spautin-1 and IM for K562 cell) |
| IUPAC Name | 6-fluoro-N-[(4-fluorophenyl)methyl]quinazolin-4-amine |
| InChI | InChI=1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20) |
| InChIKey | AWIVHRPYFSSVOG-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1CNC2=NC=NC3=C2C=C(C=C3)F)F |
| Reference | </br>1:Spautin-1 Ameliorates Acute Pancreatitis via Inhibiting Impaired Autophagy and Alleviating Calcium Overload. Xiao J, Feng X, Huang XY, Huang Z, Huang Y, Li C, Li G, Nong S, Wu R, Huang Y, Long XD.Mol Med. 2016 Aug 18;22. doi: 10.2119/molmed.2016.00034. [Epub ahead of print] PMID: 27579473 Free PMC Article</br>2:Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia. Shao S, Li S, Qin Y, Wang X, Yang Y, Bai H, Zhou L, Zhao C, Wang C.Int J Oncol. 2014 May;44(5):1661-8. doi: 10.3892/ijo.2014.2313. Epub 2014 Feb 27. PMID: 24585095 |
