Spautin-1

• CAT Number: I001061
• CAS Number: 1262888-28-7
• Molecular Formula: C₁₅H₁₁F₂N₃
• Molecular Weight: 271.26
• Purity: ≥95%
• Synonyms: (Z)-1-(4-fluorophenyl)-N-(6-fluoroquinazolin-4(3H)-ylidene)methanamine
• Target: Apoptosis
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: (1.03 μM, IM for K562 cell; 0.45 μM, Spautin-1 and IM for K562 cell)
• IUPAC Name: 6-fluoro-N-[(4-fluorophenyl)methyl]quinazolin-4-amine
• InChI: InChI=1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
• InChIKey: AWIVHRPYFSSVOG-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1CNC2=NC=NC3=C2C=C(C=C3)F)F

Spautin-1 (Cat.No:I001061) is a chemical compound known for its autophagy-modulating properties. It inhibits the activity of USP10 and USP13, deubiquitinases involved in autophagy regulation. By inhibiting these enzymes, Spautin-1 promotes autophagic degradation and has shown potential in preclinical studies for the treatment of neurodegenerative diseases and cancer.