SPDB

For research use only. Not for therapeutic Use.

  • CAT Number: I000558
  • CAS Number: 115088-06-7
  • Molecular Formula: C13H14N2O4S2
  • Molecular Weight: 326.39
  • Purity: ≥95%
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SPDB(Cat No.:I000558) is a cleavable linker commonly employed in the synthesis of antibody-drug conjugates (ADCs). It is designed to connect the antibody component of the ADC with the cytotoxic drug payload. SPDB contains a specific chemical bond that can be selectively cleaved under certain conditions, facilitating the release of the drug at the target site. This linker plays a crucial role in ADC development by providing stability during circulation and controlled drug release upon internalization by target cells, maximizing the therapeutic efficacy of the conjugate.


CAS Number 115088-06-7
Molecular Formula C13H14N2O4S2
Purity ≥95%
Target ADC Linker
Solubility Disslove in DMSO
Storage -20°C
IUPAC Name (2,5-dioxopyrrolidin-1-yl) 4-(pyridin-2-yldisulfanyl)butanoate
InChI InChI=1S/C13H14N2O4S2/c16-11-6-7-12(17)15(11)19-13(18)5-3-9-20-21-10-4-1-2-8-14-10/h1-2,4,8H,3,5-7,9H2
InChIKey JSHOVKSMJRQOGY-UHFFFAOYSA-N
SMILES C1CC(=O)N(C1=O)OC(=O)CCCSSC2=CC=CC=N2
Reference

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<br>[1]. Widdison WC et al. Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolitesin Cancer Cells andInduce High Levels of Bystander Killing.
Bioconjug Chem, 2015 Nov 18, 26(11):2261-78.

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