SPDB

• CAT Number: I000558
• CAS Number: 115088-06-7
• Molecular Formula: C13H14N2O4S2
• Molecular Weight: 326.39
• Purity: ≥95%
• Target: ADC Linker
• Solubility: Disslove in DMSO
• Storage: -20°C
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 4-(pyridin-2-yldisulfanyl)butanoate
• InChI: InChI=1S/C13H14N2O4S2/c16-11-6-7-12(17)15(11)19-13(18)5-3-9-20-21-10-4-1-2-8-14-10/h1-2,4,8H,3,5-7,9H2
• InChIKey: JSHOVKSMJRQOGY-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCCSSC2=CC=CC=N2

SPDB（Cat No.:I000558） is a cleavable linker commonly employed in the synthesis of antibody-drug conjugates (ADCs). It is designed to connect the antibody component of the ADC with the cytotoxic drug payload. SPDB contains a specific chemical bond that can be selectively cleaved under certain conditions, facilitating the release of the drug at the target site. This linker plays a crucial role in ADC development by providing stability during circulation and controlled drug release upon internalization by target cells, maximizing the therapeutic efficacy of the conjugate.

Reference

[1]. Widdison WC et al. Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolitesin Cancer Cells andInduce High Levels of Bystander Killing.
Bioconjug Chem, 2015 Nov 18, 26(11):2261-78.