SPDP

• CAT Number: I004562
• CAS Number: 68181-17-9
• Molecular Formula: C12H12N2O4S2
• Molecular Weight: 312.36
• Purity: ≥95%
• Target: ADC Linker
• Solubility: Water-insoluble (dissolve in DMF or DMSO)
• Storage: -20°C

SPDP (Cat.No:I004562) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. 

Reference

[1]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7.

[2]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708.