SPEN-IN-1

• CAT Number: I042377
• CAS Number: 2863686-82-0
• Molecular Formula: C27H20N4O
• Molecular Weight: 416.47
• Purity: ≥95%
• IUPAC Name: 3-(1H-benzimidazol-2-yl)-5-(3-phenylmethoxyphenyl)-1H-indazole
• InChI: InChI=1S/C27H20N4O/c1-2-7-18(8-3-1)17-32-21-10-6-9-19(15-21)20-13-14-23-22(16-20)26(31-30-23)27-28-24-11-4-5-12-25(24)29-27/h1-16H,17H2,(H,28,29)(H,30,31)
• InChIKey: NKMNBWKGYNRJDP-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)COC2=CC=CC(=C2)C3=CC4=C(C=C3)NN=C4C5=NC6=CC=CC=C6N5

SPEN-IN-1（Cat No.:I042377）is a small molecule inhibitor that targets SPEN (Split ends), a protein involved in the regulation of gene expression through the Wnt/β-catenin signaling pathway. SPEN plays a critical role in various biological processes, including cell differentiation, proliferation, and development. By inhibiting SPEN, SPEN-IN-1 has the potential to modulate the Wnt signaling pathway, which is often dysregulated in various cancers and developmental disorders. Research is ongoing to evaluate its therapeutic potential in cancer treatment, particularly in cancers where aberrant Wnt signaling contributes to tumor progression and metastasis.