Sphingosine (d14:1)

• CAT Number: R013834
• CAS Number: 24558-60-9
• Molecular Formula: C14H29NO2
• Molecular Weight: 243.39
• Purity: ≥95%
• Synonyms: (E,2S,3R)-2-aminotetradec-4-ene-1,3-diol
• InChI: InChI=1S/C14H29NO2/c1-2-3-4-5-6-7-8-9-10-11-14(17)13(15)12-16/h10-11,13-14,16-17H,2-9,12,15H2,1H3/b11-10+/t13-,14+/m0/s1
• InChIKey: VDRZDTXJMRRVMF-NXFSIWHZSA-N
• SMILES: CCCCCCCCCC=CC(C(CO)N)O

Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent Protein kinase C (PKC) inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters[1].

Reference

[1]. Y A Hannun, et al. Regulation of protein kinase C by sphingosine and lysosphingolipids. Clin Chim Acta. 1989 Dec 15;185(3):333-45.
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