Sphingosine Kinase Inhibitor, SKI-I

• CAT Number: I012071
• CAS Number: 306301-68-8
• Molecular Formula: C25H42N4O2
• Molecular Weight: 430.63
• Purity: ≥95%
• Synonyms: 5-naphthalen-2-yl-2H-pyrazole-3-carboxylic acid (2-hydroxy-naphthalen-1-ylmethylene)-hydrazide
• Target: A non-lipid pan-sphingosine kinase (SK) inhibitor
• Solubility: DMSO
• Storage: -20°C
• IUPAC Name: 5-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-yl)-N-[(Z)-(2-hydroxy-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-1-yl)methylideneamino]pyrazolidine-3-carboxamide
• InChI: InChI=1S/C25H42N4O2/c30-24-12-11-17-6-3-4-8-20(17)21(24)15-26-29-25(31)23-14-22(27-28-23)19-10-9-16-5-1-2-7-18(16)13-19/h15-24,27-28,30H,1-14H2,(H,29,31)/b26-15-
• InChIKey: HLRQAJDWWZYGHO-YSMPRRRNSA-N
• SMILES: C1CCC2CC(CCC2C1)C3CC(NN3)C(=O)NN=CC4C5CCCCC5CCC4O

Sphingosine Kinase Inhibitor, SKI-I (Cat No.:I012071) is a potent and selective inhibitor of sphingosine kinase 1 (SphK1) that blocks the conversion of sphingosine to sphingosine-1-phosphate (S1P). It has been shown to inhibit cell growth and induce apoptosis in cancer cells and also exhibits anti-inflammatory effects. SKI-I has been investigated as a potential therapeutic agent for cancer and inflammatory diseases and has shown promising results in preclinical studies.