For research use only. Not for therapeutic Use.
SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability[1][2].
SphK1&2-IN-1 (compound 40) (10 μM) inhibits SphK1 and SphK2 with inhibition rates of 14.3% and 26.5%, respectively[1].
SphK1&2-IN-1 (compound W4) (1-100 μM) has good thermal stability[2].
| Catalog Number | I041986 |
| CAS Number | 1415662-57-5 |
| Synonyms | (E)-3-(3,4-dimethoxyphenyl)-N-(1,3-thiazol-2-yl)prop-2-enamide |
| Molecular Formula | C14H14N2O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C14H14N2O3S/c1-18-11-5-3-10(9-12(11)19-2)4-6-13(17)16-14-15-7-8-20-14/h3-9H,1-2H3,(H,15,16,17)/b6-4+ |
| InChIKey | SMRXKMFZQYOXSX-GQCTYLIASA-N |
| SMILES | COC1=C(C=C(C=C1)C=CC(=O)NC2=NC=CS2)OC |
| Reference | [1]. Vogt D, et al. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5354-67. [2]. Nong W, et al. Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructure. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4506-4511. |
