Spironolactone

• CAT Number: A000654
• CAS Number: 52-01-7
• Molecular Formula: C24H32O4S
• Molecular Weight: 416.60
• Purity: ≥95%
• Synonyms: Aldactone; 52-01-7; Spirolactone; Verospiron; Euteberol
• Target: Androgen Receptor
• Solubility: >18mg/mL in DMSO
• Storage: -20°C
• IUPAC Name: S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate
• InChI: InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1
• InChIKey: LXMSZDCAJNLERA-ZHYRCANASA-N
• SMILES: CC(=O)S[C@@H]1CC2=CC(=O)CC[C@@]2([C@@H]3[C@@H]1[C@@H]4CC[C@]5([C@]4(CC3)C)CCC(=O)O5)C

Spironolactone（Cat No.:A000654）is a potassium-sparing diuretic and aldosterone antagonist commonly used to treat conditions like hypertension, heart failure, and edema by promoting sodium excretion and potassium retention. By blocking aldosterone receptors in the kidneys, it reduces fluid retention without significant potassium loss, unlike other diuretics. Spironolactone also has anti-androgenic properties, making it beneficial in treating acne, hirsutism, and certain hormonal disorders. Its multi-faceted action allows it to address cardiovascular, renal, and endocrine conditions, making it a valuable tool in clinical and pharmacological research.

Reference

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