SPL-B

• CAT Number: I047613
• CAS Number: 1465248-60-5
• Molecular Formula: C27H22N2O5
• Molecular Weight: 454.47
• Purity: ≥95%
• IUPAC Name: 8-[[ethyl(pyridin-4-ylmethyl)amino]methyl]-7-hydroxy-4-(2-oxochromen-3-yl)chromen-2-one
• InChI: InChI=1S/C27H22N2O5/c1-2-29(15-17-9-11-28-12-10-17)16-22-23(30)8-7-19-20(14-25(31)34-26(19)22)21-13-18-5-3-4-6-24(18)33-27(21)32/h3-14,30H,2,15-16H2,1H3
• SMILES: CCN(CC1=CC=NC=C1)CC2=C(C=CC3=C2OC(=O)C=C3C4=CC5=CC=CC=C5OC4=O)O

Orally active inhibitor of transforming acidic coiled-coil protein (TACC3) that selectively inhibits the nucleation of centrosome microtubules in ovarian cancer cells, without affecting spindle assembly in normal cells. SPL significantly inhibits mitosis in cancer cells and suppresses in vivo tumor growth.
KEYWORDS: SPL-B | supplier | TACC3 inhibitor | Spindlactone B | SPLB | CAS [1465248-60-5] | microtubules | MTs | TACC | Inhibitor | proteins | mitotic spindle | assembly | mitosis | centrosomal | TOGp | Aurora A | coumarin | cell-cycle regulation | differentiation

Reference

R. Yao et al. A small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells. Oncogene. 2014 Aug 14;33(33):4242-52.