Spliceostatin A

• CAT Number: I009788
• CAS Number: 391611-36-2
• Molecular Formula: C28H43NO8
• Molecular Weight: 521.651
• Purity: ≥95%
• Synonyms: Spliceostatin A; (2Z,4S)-4-(Acetyloxy)-N-[(2R,3R,5S,6S)-tetrahydro-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4-hydroxy-7-methoxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadien-1-yl]-2,5-dimethyl-2H-pyran-3-yl]-2-pentenamide
• Target: SF3B1
• Storage: Room temperature
• IUPAC Name: [(Z,2S)-5-[[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4-hydroxy-7-methoxy-7-methyl-1,6-dioxaspiro[2.5]octan-5-yl]-3-methylpenta-2,4-dienyl]-2,5-dimethyloxan-3-yl]amino]-5-oxopent-3-en-2-yl] acetate
• InChI: InChI=1S/C28H43NO8/c1-17(9-12-24-26(32)28(16-34-28)15-27(6,33-7)37-24)8-11-23-18(2)14-22(20(4)36-23)29-25(31)13-10-19(3)35-21(5)30/h8-10,12-13,18-20,22-24,26,32H,11,14-16H2,1-7H3,(H,29,31)/b12-9+,13-10-,17-8+/t18-,19-,20+,22+,23-,24+,26+,27-,28+/m0/s1
• InChIKey: XKSGIJNRMWHQIQ-CGPJBNNXSA-N
• SMILES: CC1CC(C(OC1CC=C(C)C=CC2C(C3(CC(O2)(C)OC)CO3)O)C)NC(=O)C=CC(C)OC(=O)C

Spliceostatin A (CAT: I009788) is a natural product derived from the bacterium Pseudomonas chartarum. It is a potent inhibitor of pre-mRNA splicing, a crucial step in gene expression. Spliceostatin A targets the spliceosome, a large ribonucleoprotein complex responsible for the removal of introns and the splicing together of exons during mRNA maturation. By inhibiting the spliceosome, spliceostatin A disrupts the splicing process and alters mRNA processing, leading to the accumulation of aberrant splicing products and ultimately affecting protein production. Due to its ability to modulate splicing, spliceostatin A has attracted interest in both basic research and potential therapeutic applications for diseases related to splicing dysregulation, such as cancer.

Reference

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