S.pombe lumazine synthase-IN-1

• CAT Number: I015328
• CAS Number: 331726-35-3
• Molecular Formula: C₁₄H₁₃N₃O₆
• Molecular Weight: 319.27
• Purity: ≥95%
• Target: Bacterial
• IUPAC Name: 6-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-5-nitro-1H-pyrimidine-2,4-dione
• InChI: InChI=1S/C14H13N3O6/c1-22-10-6-4-8(7-11(10)23-2)3-5-9-12(17(20)21)13(18)16-14(19)15-9/h3-7H,1-2H3,(H2,15,16,18,19)/b5-3+
• InChIKey: PKSLOHMKDSSQHQ-HWKANZROSA-N
• SMILES: COC1=C(C=C(C=C1)/C=C/C2=C(C(=O)NC(=O)N2)[N+](=O)[O-])OC

S. pombe lumazine synthase-IN-1（Cat No.:I015328）is a small molecule inhibitor specifically targeting lumazine synthase in Schizosaccharomyces pombe (S. pombe), a model organism for cell biology studies. Lumazine synthase plays a critical role in the biosynthesis of riboflavin (vitamin B2), making this inhibitor valuable in research focused on metabolic pathways and enzyme functions. By selectively inhibiting this enzyme, S. pombe lumazine synthase-IN-1 aids in understanding riboflavin biosynthesis and its regulation, offering insights into potential applications for antifungal and antimicrobial drug development targeting similar pathways in pathogenic organisms.

Reference

[1]. Arindam Talukdar, et al. Discovery and Development of a Small Molecule Library With Lumazine Synthase Inhibitory Activity. J Org Chem. 2009 Aug 7;74(15):5123-34.