SPP 86

• CAT Number: I011184
• CAS Number: 1357349-91-7
• Molecular Formula: C16H15N5
• Molecular Weight: 277.331
• Purity: ≥95%
• Synonyms: 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• Target: RET
• Solubility: Soluble to 100 mM in DMSO and to 20 mM in ethanol
• Storage: Store at +4C
• IUPAC Name: 3-(2-phenylethynyl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
• InChI: InChI=1S/C16H15N5/c1-11(2)21-16-14(15(17)18-10-19-16)13(20-21)9-8-12-6-4-3-5-7-12/h3-7,10-11H,1-2H3,(H2,17,18,19)
• InChIKey: JQOIRTDBHMDWMT-UHFFFAOYSA-N
• SMILES: CC(C)N1C2=C(C(=N1)C#CC3=CC=CC=C3)C(=NC=N2)N

SPP 86(CAT: I011184) is a potent inhibitor targeting the RET (rearranged during transfection) kinase with notable efficacy, demonstrated by an impressive IC50 value of 8 nM. This compound also exhibits inhibitory activity towards several other kinases, including EphA1, FGFR1, Flt4, Lck, and Yes. Notably, it effectively suppresses the proliferation of HCT 116 and TPC1 cells in vitro, hinting at its potential as an antiproliferative agent for cancer therapy.