For research use only. Not for therapeutic Use.
SPP-DM1（Cat No.:I017863）, also known as Sulfasalazine-DM1, is a conjugate molecule consisting of the chemotherapeutic agent DM1 (maytansine derivative) linked to SPP (sulfasalazine) via a linker. It is designed as an antibody-drug conjugate (ADC) payload. SPP-DM1 combines the tumor-targeting properties of an antibody with the potent cytotoxicity of DM1, allowing for targeted delivery of the drug to cancer cells.
| Catalog Number | I017863 |
| CAS Number | 452072-20-7 |
| Molecular Formula | C₄₄H₅₉ClN₄O₁₄S₂ |
| Purity | ≥95% |
| Target | Drug-Linker Conjugates for ADC |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 4-[[3-[[(2S)-1-[[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl]oxy]-1-oxopropan-2-yl]-methylamino]-3-oxopropyl]disulfanyl]pentanoate |
| InChI | InChI=1S/C44H59ClN4O14S2/c1-24-11-10-12-32(59-9)44(57)23-31(60-42(56)46-44)26(3)40-43(5,62-40)33(22-37(53)48(7)29-20-28(19-24)21-30(58-8)39(29)45)61-41(55)27(4)47(6)34(50)17-18-64-65-25(2)13-16-38(54)63-49-35(51)14-15-36(49)52/h10-12,20-21,25-27,31-33,40,57H,13-19,22-23H2,1-9H3,(H,46,56)/b12-10+,24-11+/t25?,26-,27+,31+,32-,33+,40+,43+,44+/m1/s1 |
| InChIKey | ZMOVORWFEGTIJA-MUZJBSEYSA-N |
| SMILES | CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)N(C)C(=O)CCSSC(C)CCC(=O)ON5C(=O)CCC5=O)C)C)OC)(NC(=O)O2)O |
| Reference | [1]. Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules. |
