For research use only. Not for therapeutic Use.
SQ609 is a lead compound from a library of dipiperidines. SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells. SQ609 displays a potent antitubercular activity [1].
In Mtb-infected macrophages in vitro, SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells[1].
SQ609 (10 mg/kg; intravenous injection) completely prevents weight loss in the Mtb-infected animals and prolongs the therapeutic effect following drug withdrawal for another 10-15 days[1].
| Catalog Number | I044405 |
| CAS Number | 627052-25-9 |
| Synonyms | 1-[[1-(1-adamantylmethyl)piperidin-4-yl]methyl]piperidin-4-ol |
| Molecular Formula | C22H38N2O |
| Purity | ≥95% |
| InChI | InChI=1S/C22H38N2O/c25-21-3-7-23(8-4-21)15-17-1-5-24(6-2-17)16-22-12-18-9-19(13-22)11-20(10-18)14-22/h17-21,25H,1-16H2 |
| InChIKey | YUBKDPOCUHUSLW-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1CN2CCC(CC2)O)CC34CC5CC(C3)CC(C5)C4 |
| Reference | [1]. Bogatcheva E, et al. Identification of SQ609 as a lead compound from a library of dipiperidines. Bioorg Med Chem Lett. 2011;21(18):5353-5357. |
