For research use only. Not for therapeutic Use.
Squalamine lactate (Cat No.:I013055) is an aminosterol compound originally derived from the tissues of the dogfish shark. It exhibits antimicrobial activity, making it useful in the treatment of various infections. Additionally, squalamine lactate has been studied for its potential therapeutic application in neovascular age-related macular degeneration (AMD), a condition characterized by abnormal blood vessel growth in the retina. It has shown promise in inhibiting angiogenesis, the formation of new blood vessels, and has been investigated as a treatment option to prevent the progression of neovascular AMD. The unique properties of squalamine lactate make it a subject of interest for both antimicrobial and ocular therapeutic applications.
| Catalog Number | I013055 |
| CAS Number | 320725-47-1 |
| Molecular Formula | C₃₇H₇₁N₃O₈S |
| Purity | ≥95% |
| Target | Bacterial |
| Solubility | DMSO: ≥ 36.66 mg/mL |
| Overview of Clinical Research | OriginatorGenaera Corporation<br /> |
| IUPAC Name | [(3R,6R)-6-[(3S,5R,7R,8R,9S,10S,13R,14S,17R)-3-[3-(4-aminobutylamino)propylamino]-7-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylheptan-3-yl] hydrogen sulfate;(2S)-2-hydroxypropanoic acid |
| InChI | InChI=1S/C34H65N3O5S.C3H6O3/c1-23(2)31(42-43(39,40)41)12-9-24(3)27-10-11-28-32-29(14-16-34(27,28)5)33(4)15-13-26(21-25(33)22-30(32)38)37-20-8-19-36-18-7-6-17-35;1-2(4)3(5)6/h23-32,36-38H,6-22,35H2,1-5H3,(H,39,40,41);2,4H,1H3,(H,5,6)/t24-,25-,26+,27-,28+,29+,30-,31-,32+,33+,34-;2-/m10/s1 |
| InChIKey | JMNXSNUXDHHTKQ-QVMSTPCGSA-N |
| SMILES | CC(C)C(CCC(C)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)NCCCNCCCCN)C)O)C)OS(=O)(=O)O.CC(C(=O)O)O |
| Reference | [1]. Hussain RM, et al. Emerging vascular endothelial growth factor antagonists to treat neovascular age-related macular degeneration. Expert Opin Emerg Drugs. 2017 Sep;22(3):235-246.<br /> |
