For research use only. Not for therapeutic Use.
SR-0813 is a novel potent and selective ENL/AF9 YEATS domain inhibitor (IC50 = 25 nM). SR-0813 as a useful chemical probe to study ENL/AF9 YEATS domain biology. SR-0813 represents timely additions to the collection of tools available for studying ENL and AF9 YEATS domains, as many aspects of ENL biology remain poorly understood.
| Catalog Number | I036580 |
| CAS Number | 2597186-19-9 |
| Synonyms | SR-0813; SR0813; SR 0813; |
| Molecular Formula | C25H32N6O3S |
| Purity | 98% |
| Target | Epigenetic Reader Domain |
| Solubility | To be determined |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | N-cyclobutyl-2-(3-((N-(2-(piperidin-1-yl)ethyl)sulfamoyl)amino)phenyl)imidazo[1,2-a]pyridine-6-carboxamide |
| InChI | InChI=1S/C25H32N6O3S/c32-25(27-21-7-5-8-21)20-10-11-24-28-23(18-31(24)17-20)19-6-4-9-22(16-19)29-35(33,34)26-12-15-30-13-2-1-3-14-30/h4,6,9-11,16-18,21,26,29H,1-3,5,7-8,12-15H2,(H,27,32) |
| InChIKey | GPMTWAPXRJMXCC-UHFFFAOYSA-N |
| SMILES | O=C(C1=CN2C(C=C1)=NC(C3=CC=CC(NS(=O)(NCCN4CCCCC4)=O)=C3)=C2)NC5CCC5 |
| Reference | 1: Garnar-Wortzel L, Bishop TR, Kitamura S, Milosevich N, Asiaban JN, Zhang X, Zheng Q, Chen E, Ramos AR, Ackerman CJ, Hampton EN, Chatterjee AK, Young TS, Hull MV, Sharpless KB, Cravatt BF, Wolan DW, Erb MA. Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia. ACS Cent Sci. 2021 May 26;7(5):815-830. doi: 10.1021/acscentsci.0c01550. Epub 2021 Apr 30. PMID: 34079898; PMCID: PMC8161486. |
