SR-0813

• CAT Number: I036580
• CAS Number: 2597186-19-9
• Molecular Formula: C25H32N6O3S
• Molecular Weight: 496.63
• Purity: 98%
• Synonyms: SR-0813; SR0813; SR 0813
• Target: Epigenetic Reader Domain
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-cyclobutyl-2-(3-((N-(2-(piperidin-1-yl)ethyl)sulfamoyl)amino)phenyl)imidazo[1,2-a]pyridine-6-carboxamide
• InChI: InChI=1S/C25H32N6O3S/c32-25(27-21-7-5-8-21)20-10-11-24-28-23(18-31(24)17-20)19-6-4-9-22(16-19)29-35(33,34)26-12-15-30-13-2-1-3-14-30/h4,6,9-11,16-18,21,26,29H,1-3,5,7-8,12-15H2,(H,27,32)
• InChIKey: GPMTWAPXRJMXCC-UHFFFAOYSA-N
• SMILES: O=C(C1=CN2C(C=C1)=NC(C3=CC=CC(NS(=O)(NCCN4CCCCC4)=O)=C3)=C2)NC5CCC5

SR-0813 (Cat No.: I036580) is a selective small-molecule inhibitor of ENL (eleven-nineteen leukemia), a chromatin reader protein involved in transcriptional regulation and oncogenic gene expression, particularly in acute leukemia. By disrupting ENL’s interaction with chromatin, SR-0813 impairs the expression of key leukemogenic genes such as HOXA9 and MYC. It exhibits strong antiproliferative effects in ENL-dependent leukemia cell lines and represents a novel therapeutic approach targeting epigenetic regulation. SR-0813 is a valuable tool in cancer research and drug development focused on transcriptional coactivator proteins.

Reference

1: Garnar-Wortzel L, Bishop TR, Kitamura S, Milosevich N, Asiaban JN, Zhang X, Zheng Q, Chen E, Ramos AR, Ackerman CJ, Hampton EN, Chatterjee AK, Young TS, Hull MV, Sharpless KB, Cravatt BF, Wolan DW, Erb MA. Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia. ACS Cent Sci. 2021 May 26;7(5):815-830. doi: 10.1021/acscentsci.0c01550. Epub 2021 Apr 30. PMID: 34079898; PMCID: PMC8161486.