SR 0987

• CAT Number: I011323
• CAS Number: 303126-97-8
• Molecular Formula: C16H10ClF6NO2
• Molecular Weight: 397.701
• Purity: ≥95%
• Synonyms: 2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
• Target: ROR
• Solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
• Storage: Store at +4C
• IUPAC Name: 2-chloro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzamide
• InChI: InChI=1S/C16H10ClF6NO2/c17-12-4-2-1-3-11(12)13(25)24-10-7-5-9(6-8-10)14(26,15(18,19)20)16(21,22)23/h1-8,26H,(H,24,25)
• InChIKey: IZVBONMVWLTLNT-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O)Cl

SR 0987(CAT: I011323) is a T cell-specific agonist of the retinoic acid receptor-related orphan receptor gamma (RORγ or RORγt). RORγ is a transcription factor involved in the development and function of T cells, particularly T helper 17 (Th17) cells. By activating RORγ, SR 0987 promotes the differentiation and proliferation of Th17 cells, which play a crucial role in immune responses and inflammation. SR 0987 has demonstrated its potency in a gene reporter assay with an EC50 of 800 nM, indicating its ability to specifically target and activate RORγ in T cells.