For research use only. Not for therapeutic Use.
SR 11237 is a pan retinoid X receptor (RXR) agonist.
| Catalog Number | I009576 |
| CAS Number | 146670-40-8 |
| Synonyms | SR 11237; SR11237; SR-11237; BMS 649; BMS-649.;4-(2-(5,6,7,8-Tetrahydro-5,5,8,8,-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl)benzoic acid |
| Molecular Formula | C24H28O4 |
| Purity | ≥95% |
| Target | Vitamin D Related/Nuclear Receptor |
| Solubility | Soluble in DMSO |
| Storage | Store at -20 °C |
| IUPAC Name | 4-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-1,3-dioxolan-2-yl]benzoic acid |
| InChI | InChI=1S/C24H28O4/c1-22(2)11-12-23(3,4)20-15-18(9-10-19(20)22)24(27-13-14-28-24)17-7-5-16(6-8-17)21(25)26/h5-10,15H,11-14H2,1-4H3,(H,25,26) |
| InChIKey | ZZUKALQMHNSWTK-UHFFFAOYSA-N |
| SMILES | CC1(CCC(C2=C1C=CC(=C2)C3(OCCO3)C4=CC=C(C=C4)C(=O)O)(C)C)C |
| Reference | </br>1:Giner XC, Cotnoir-White D, Mader S, Lévesque D. Selective ligand activity at Nur/retinoid X receptor complexes revealed by dimer-specific bioluminescence resonance energy transfer-based sensors. FASEB J. 2015 Oct;29(10):4256-67. doi: 10.1096/fj.14-259804. PubMed PMID: 26148973.</br>2:Ning RB, Zhu J, Chai DJ, Xu CS, Xie H, Lin XY, Zeng JZ, Lin JX. RXR agonists inhibit high glucose-induced upregulation of inflammation by suppressing activation of the NADPH oxidase-nuclear factor-κB pathway in human endothelial cells. Genet Mol Res. 2013 Dec 13;12(4):6692-707. doi: 10.4238/2013.December.13.3. PubMed PMID: 24391011. |
