SR 11237

• CAT Number: I009576
• CAS Number: 146670-40-8
• Molecular Formula: C24H28O4
• Molecular Weight: 380.48
• Purity: ≥95%
• Synonyms: SR 11237; SR11237; SR-11237; BMS 649; BMS-649.;4-(2-(5,6,7,8-Tetrahydro-5,5,8,8,-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl)benzoic acid
• Target: Vitamin D Related/Nuclear Receptor
• Solubility: Soluble in DMSO
• Storage: Store at -20 °C
• IUPAC Name: 4-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-1,3-dioxolan-2-yl]benzoic acid
• InChI: InChI=1S/C24H28O4/c1-22(2)11-12-23(3,4)20-15-18(9-10-19(20)22)24(27-13-14-28-24)17-7-5-16(6-8-17)21(25)26/h5-10,15H,11-14H2,1-4H3,(H,25,26)
• InChIKey: ZZUKALQMHNSWTK-UHFFFAOYSA-N
• SMILES: CC1(CCC(C2=C1C=CC(=C2)C3(OCCO3)C4=CC=C(C=C4)C(=O)O)(C)C)C

SR 11237（Cat No.:I009576）is a small molecule compound that acts as a selective antagonist of the histamine H3 receptor (H3R), a G-protein-coupled receptor involved in regulating neurotransmitter release and various brain functions. By blocking H3R, SR 11237 is thought to enhance the release of neurotransmitters like acetylcholine, dopamine, and norepinephrine, which may improve cognitive function and have potential applications in treating neurodegenerative disorders, such as Alzheimer’s disease, and conditions related to cognitive decline. It is being studied for its potential to modulate brain activity and improve memory and attention.

Reference

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